- ►diabetesjournals.org JV Busik, S Mohr, MB Grant - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—Glucose consumption of HRECs, human retinal pigment
epithelial cells (HRPEs), and human Müller cells (HMCs) under elevated glucose conditions
was measured and compared with cytokine treatment. Production of ROS in HRECs was ... Cited by 16 - Related articles - All 5 versions
X Xi, L Gao, DA Hatala, DG Smith, MC Codispoti, B … - … and biophysical research …, 2005 - Elsevier Hyperglycemia induces apoptotic cell death in a variety of cell types in diabetes, and the mechanism
remains unclear. We report here that culture of rat retinal glial Müller cells in 25 mM glucose
for 72 h significantly inactivated Akt and induced apoptosis. Likewise, hyperglycemia ... Cited by 8 - Related articles - All 5 versions
JA Vincent, S Mohr - Diabetes, 2007 - Am Diabetes Assoc The proinflammatory cytokine, interleukin (IL)-1β, is known to induce vascular dysfunction and
cell death. We investigated the role of IL-1β and caspase-1 (the enzyme that produces it) in
diabetes-induced degeneration of retinal capillaries. Caspase-1 activity is increased in ... Cited by 19 - Related articles - BL Direct - All 5 versions
- ►iovs.org RJ Walker, JJ Steinle - Investigative Ophthalmology & Visual Science, 2007 - ARVO RESULTS. Isoproterenol treatment significantly decreased protein levels of iNOS, TNF- , and
IL-1B, in rMC-1 cells cultured in high glucose as early as 1 hour, compared with cells receiving
no treatment. PGE2 content was also reduced after isoproterenol treatment. There were ... Cited by 3 - Related articles - BL Direct - All 2 versions
E Nobécourt, J Zeng, MJ Davies, BE Brown, S Yadav, … - Diabetologia, 2008 - Springer Abstract Aims/hypothesis Hyperglycaemia, a key feature of diabetes, is associated with non-enzymatic
glycation of plasma proteins. We have shown previously that the reactive α- oxoaldehyde,
methylglyoxal, non-enzymatically glycates apolipoprotein (Apo)AI, the main ... Cited by 4 - Related articles - BL Direct - All 2 versions
MC CARRERAS, M MELANI, N RIOBO, DP … - Methods in enzymology, 2002 - cat.inist.fr Neuronal nitric oxide synthases in brain and extraneural tissues. Maria Cecilia CARRERAS,
Mariana MELANI, Natalia RIOBO, Daniela P CONVERSO, Emiilia M GATTO, Juan José
PODEROSO Methods in enzymology 359, 413-423, Elsevier, 2002.
Cited by 5 - Related articles - BL Direct - All 2 versions
- ►diabetesjournals.org M Kanwar, RA Kowluru - Diabetes, 2009 - Am Diabetes Assoc OBJECTIVE—Mitochondrial superoxide levels are elevated in the retina in diabetes, and manganese
superoxide dismutase overexpression prevents the development of retinopathy. Superoxide
inhibits glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which activates major ... Cited by 6 - Related articles - All 3 versions
KM Desai, L Wu - Drug metabolism and drug interactions, 2008 - ncbi.nlm.nih.gov Methylglyoxal (MG) is a reactive dicarbonyl intermediate of the glycolytic pathway. Increased
oxidative stress is associated with conditions of increased MG, such as diabetes mellitus. Increased
oxidative stress is due to an increase in highly reactive by-products of metabolic ... Cited by 7 - Related articles - BL Direct
K Desai, L Wu - Recent Patents on Cardiovascular Drug Discovery, 2007 - ingentaconnect.com Received: January 19, 2007; Accepted: February 19, 2007; Revised: March 27, 2007
Abstract: Advanced glycation endproducts (AGEs) are unavoidable byproducts of various metabolic
pathways. They are formed by reactive metabolic intermediates such as methylglyoxal ... Cited by 8 - Related articles - BL Direct - All 2 versions
S Mohr - eid, 2004 - informahealthcare.com Recent studies have demonstrated that diabetic retinopathy has several characteristics of a chronic
inflammatory disease, such as increased nitric oxide production, intracellular adhesion
molecule-1 upregulation, leukostasis and increased vascular permeability. In addition, ... Cited by 20 - Related articles - All 5 versions
