DA Sandoval, D Bagnol, SC Woods, DA D'Alessio, RJ … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—We found that central, but not peripheral, administration of low doses of a GLP-1
receptor antagonist caused relative hyperglycemia during a glucose tolerance test, suggesting
that activation of central GLP-1 receptors regulates key processes involved in the ... Cited by 19 - Related articles - All 4 versions
- ►endojournals.org MR Hayes, KP Skibicka, HJ Grill - Endocrinology, 2008 - Endocrine Soc The effects of peripheral glucagon like peptide-1 receptor (GLP-1R) stimulation on feeding, gastric
emptying, and energetic responses involve vagal transmission and central nervous system
processing. Despite a lack of studies aimed at determining which central nervous system ... Cited by 12 - Related articles - All 6 versions
C Knauf, PD Cani, DH Kim, MA Iglesias, C Chabo, A … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—Ingested glucose is detected by specialized sensors in the enteric/hepatoportal
vein, which send neural signals to the brain, which in turn regulates key peripheral tissues.
Hence, impairment in the control of enteric-neural glucose sensing could contribute to ... Cited by 13 - Related articles - All 8 versions
[CITATION] de BP, Luiten PG, van Willigen JD. Ascending projections from the solitary tract …
- ►physiology.org HJ Grill, JS Carmody, L Amanda Sadacca, … - American Journal of …, 2004 - Am Physiological Soc The central glucagon-like peptide-1 (GLP-1) system has been implicated in the control of feeding
behavior. Here we explore GLP-1 mediation of the anorexic response to administration of systemic
LPS and address the relative importance of caudal brain stem and forebrain GLP-1 ... Cited by 17 - Related articles - All 4 versions
S Wan, KN Browning, RA Travagli - Peptides, 2007 - Elsevier Using a brainstem slice preparation, we aimed to study the pre- and postsynaptic effects of
glucagon-like peptide-1 (GLP-1) on synaptic transmission to identified pancreas-projecting vagal
motoneurons. Following blockade of GABAergic mediated currents with bicuculline, ... Cited by 5 - Related articles - All 3 versions
DL Williams, DG Baskin, MW Schwartz - Endocrinology, 2009 - Endocrine Soc A physiological role in satiety is proposed for glucagon-like peptide-1 (GLP-1), secreted by the
distal intestine in response to ingested nutrients. Here we report that in rats, ip injection of the
GLP-1 receptor (GLP-1-R) antagonist exendin 9-39 (Ex9) elicited hyperphagia, but only at ... Cited by 7 - Related articles - All 3 versions
- ►nih.gov J Chen, KA Scott, Z Zhao, TH Moran, S Bi - Neuroscience, 2008 - Elsevier Within the dorsomedial hypothalamus (DMH), cholecystokinin (CCK) has been proposed to modulate
neuropeptide Y (NPY) signaling to affect food intake. However, the neural circuitry underlying
the actions of this CCK-NPY signaling system in the controls of food intake has yet to be ... Cited by 7 - Related articles - All 4 versions
X Ma, J Bruning, FM Ashcroft - Journal of Neuroscience, 2007 - neuro.cjb.net Glucagon-likepeptide1(GLP-1)isapotentinhibitoroffoodintake.GLP-1receptormRNAisdenselyexpressedinhypothalamicarcuate
nucleus (ARC) and precisely overlaps the area occupied by proopiomelanocortin (POMC)
neurons. Activation of POMC neurons sup- pressesappetite,andlackofPOMC- ... Cited by 22 - Related articles - View as HTML - All 4 versions
- ►diabetesjournals.org RJ McCrimmon, M Shaw, X Fan, H Cheng, Y Ding, MC … - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—Using gene silencing technology to selectively downregulate
AMPK in the VMH, a key hypothalamic glucose-sensing region, we demonstrate a key role for
AMPK in the detection of hypoglycemia. In vivo hyperinsulinemic-hypoglycemic (50 mg dl ... Cited by 12 - Related articles - BL Direct - All 3 versions
