- ►diabetesjournals.org CP Tan, Y Feng, YP Zhou, GJ Eiermann, A Petrov, C … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE— Acute activation of G protein–coupled receptor 40 (GPR40) by free fatty acids
(FFAs) or synthetic GPR40 agonists enhances insulin secretion. However, it is still a matter of
debate whether activation of GPR40 would be beneficial for the treatment of type 2 ... Cited by 17 - Related articles - All 5 versions
M Kebede, T Alquier, MG Latour, M Semache, C … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—The G-protein–coupled receptor GPR40 is expressed in pancreatic β-cells and
is activated by long-chain fatty acids. Gene deletion studies have shown that GPR40
mediates, at least in part, fatty acid–amplification of glucose-induced insulin secretion ... Cited by 13 - Related articles - All 4 versions
R Brownlie, R Mayers, J Pierce, A Marley, … - Biochemical Society …, 2008 - biochemsoctrans.org GPR40 (G-protein-coupled receptor 40) has been shown to be a physiologically relevant receptor
for long-chain fatty acids. It is a family A G-protein-coupled receptor highly expressed in the
β-cell where it increases insulin secretion by signalling via G q and phospholipase C. ... Cited by 5 - Related articles - Cached - All 4 versions
H Lan, LM Hoos, L Liu, G Tetzloff, W Hu, SJ … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—FFAR1/GPR40 is a G-protein–coupled receptor expressed predominantly in pancreatic
islets mediating free fatty acid–induced insulin secretion. However, the physiological role of FFAR1
remains controversial. It was previously reported that FFAR1 knockout (Ffar1 −/− ) mice ... Cited by 9 - Related articles - All 5 versions
E Flodgren, B Olde, S Meidute-Abaraviciene, MS … - … and Biophysical Research …, 2007 - Elsevier The free fatty acid receptor, GPR40, has been coupled with insulin secretion via its expression
in pancreatic β-cells. However, the role of GPR40 in the release of glucagon has not been studied
and previous attempts to identify the receptor in α-cells have been unfruitful. Using ... Cited by 15 - Related articles - All 5 versions
- ►jbc.org LA Stoddart, NJ Smith, L Jenkins, AJ Brown, G … - Journal of Biological …, 2008 - ASBMB FFA2 and FFA3 are closely related G protein-coupled receptors that bind and respond to short
chain fatty acids. (FFA2 and FFA3 are the provisional International Union of Pharmacology designations
for the receptors previously called GPR43 and GPR41, respectively.) Sequence ... Cited by 4 - Related articles - All 3 versions
- ►jbc.org CS Sum, IG Tikhonova, S Neumann, S Engel, BM … - Journal of Biological …, 2007 - ASBMB GPR40 was formerly an orphan G protein-coupled receptor whose endogenous ligands have
recently been identified as free fatty acids (FFAs). The receptor, now named FFA receptor 1, has
been implicated in the pathophysiology of type 2 diabetes and is a drug target because of ... Cited by 17 - Related articles - All 6 versions
- ►pubget.com [PDF] LA Stoddart, NJ Smith, G Milligan - Pharmacological reviews, 2008 - ASPET Identification of G protein-coupled receptors that are activated by free fatty acids has led to considerable
interest in their pharmacology and function because of the wide range of normal physiology and
disease states in which fatty acids have been implicated. Free fatty acid receptor (FFA) 1 ... Cited by 9 - Related articles - All 5 versions
S Costanzi, S Neumann, MC Gershengorn - Journal of Biological Chemistry, 2008 - ASBMB Free fatty acids (FFAs) 2 take part in many physiological processes in different tissues such as
skeletal muscle, liver, heart, and pancreas by providing an oxidative energy source. In
addition, FFAs are potent signaling molecules (1). Dysregulation of FFA metabolism is ... Cited by 9 - Related articles - All 6 versions
- ►endojournals.org R Vettor, M Granzotto, D De Stefani, E Trevellin, … - Journal of Clinical …, 2008 - Endocrine Soc Study Design and Results: For in vivo studies, we screened 734 subjects for the coding region
of GPR40 and identified a new single-nucleotide mutation (Gly180Ser). The mean allele frequency
was 0.75%, which progressively increased (P < 0.05) from nonobese subjects (0.42%) to ... Cited by 5 - Related articles - All 4 versions
