- ►nih.gov S Edfalk, P Steneberg, H Edlund - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—The G-protein–coupled receptor Gpr40 is expressed in β-cells
where it contributes to free fatty acid (FFA) enhancement of glucose-stimulated
insulin secretion (1–4). However, other sites of Gpr40 expression, ... Cited by 15 - Related articles - All 4 versions
H Lan, LM Hoos, L Liu, G Tetzloff, W Hu, SJ … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—FFAR1/GPR40 is a G-protein–coupled receptor expressed
predominantly in pancreatic islets mediating free fatty acid–induced insulin
secretion. However, the physiological role of FFAR1 remains controversial. ... Cited by 9 - Related articles - All 5 versions
- ►diabetesjournals.org CP Tan, Y Feng, YP Zhou, GJ Eiermann, A … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE— Acute activation of G protein–coupled receptor 40 (GPR40) by free
fatty acids (FFAs) or synthetic GPR40 agonists enhances insulin secretion.
However, it is still a matter of debate whether activation of GPR40 would ... Cited by 17 - Related articles - All 5 versions
- ►jbc.org R Bartoov-Shifman, G Ridner, K Bahar, N … - Journal of Biological Chemistry, 2007 - ASBMB GPR40 is a G protein-coupled receptor expressed preferentially in pancreatic
cells. It is activated by long-chain fatty acids and has been implicated in
mediating physiological and pathological effects of long-chain fatty acids ... Cited by 8 - Related articles - All 6 versions
- ►nih.gov M Kebede, T Alquier, MG Latour, M Semache, … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—The G-protein–coupled receptor GPR40 is expressed in pancreatic
β-cells and is activated by long-chain fatty acids. Gene deletion studies have
shown that GPR40 mediates, at least in part, fatty acid–amplification of ... Cited by 13 - Related articles - All 4 versions
- ►pubget.com [PDF] LA Stoddart, NJ Smith, G Milligan - Pharmacological reviews, 2008 - ASPET Identification of G protein-coupled receptors that are activated by free fatty
acids has led to considerable interest in their pharmacology and function
because of the wide range of normal physiology and disease states in which ... Cited by 9 - Related articles - All 5 versions
E Flodgren, B Olde, S Meidute-Abaraviciene, … - Biochemical and Biophysical Research …, 2007 - Elsevier The free fatty acid receptor, GPR40, has been coupled with insulin secretion via
its expression in pancreatic β-cells. However, the role of GPR40 in the release
of glucagon has not been studied and previous attempts to identify the ... Cited by 15 - Related articles - All 5 versions
- ►diabetesjournals.org K Nagasumi, R Esaki, K Iwachidow, Y … - Diabetes, 2009 - Am Diabetes Assoc RESULTS In comparison with nontransgenic littermates, hGPR40 transgenic mice
exhibited improved oral glucose tolerance with an increase in insulin secretion.
Although islet morphologic analysis showed no obvious differences between ... Cited by 7 - Related articles - All 4 versions
E Christiansen, C Urban, N Merten, K … - J. Med. Chem, 2008 - pubs.acs.org A series of 4-phenethynyldihydrocinnamic acid agonists of the free fatty acid
receptor 1 (FFA 1 ) has been discovered and explored. The preferred compound 20
(TUG-424, EC 50 = 32 nM) significantly increased glucose-stimulated insulin ... Cited by 7 - Related articles - All 3 versions
LS Doshi, MK Brahma, SG Sayyed, AV Dixit, … - Metabolism: clinical and experimental, 2009 - ncbi.nlm.nih.gov Recently, several in vitro studies have shown that GPR40 receptor activation by
free fatty acids (FFAs) results in glucose-dependent insulin secretion. However,
whether GPR40 receptor activation results in glucose-dependent insulin ... Cited by 3 - Related articles - All 6 versions
