- ►diabetesjournals.org T Kato, H Shimano, T Yamamoto, M Ishikawa, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Incubation of C57BL/6 islets with palmitate caused inhibition of both
glucose- and potassium-stimulated insulin secretion, but addition of
eicosapentaenoate (EPA) restored both inhibitions. Concomitantly, palmitate ... Cited by 11 - Related articles - All 6 versions
H Shimano, M Amemiya-Kudo, A Takahashi, T … - Diabetes Obes Metab, 2007 - interscience.wiley.com It has long been known that excess intracellular fatty acids cause impaired
insulin secretion, referred to as β-cell lipotoxicity. Sterol regulatory
element–binding protein (SREBP)-1c is a transcription factor that ... Cited by 10 - Related articles - All 2 versions
- ►umin.ac.jp [PDF] T Kato, H Shimano, T Yamamoto, T Yokoo, Y … - Cell Metabolism, 2006 - Elsevier Granuphilin is a crucial component of the docking machinery of
insulin-containing vesicles to the plasma membrane. Here, we show that the
granuphilin promoter is a target of SREBP-1c, a transcription factor that ... Cited by 25 - Related articles - All 8 versions
H Shimano - FEBS J, 2009 - interscience.wiley.com Sterol regulatory element-binding proteins (SREBPs) have been established as
physiological regulators of lipid synthesis. The molecular mechanisms by which
cellular sterol balance and nutritional states regulate SREBP activities ... Cited by 6 - Related articles - All 4 versions
M Nakakuki, H Shimano, N Inoue, M Tamura, … - FEBS journal, 2007 - lipid.umin.ne.jp 1 Department of Internal Medicine (Endocrinology and Metabolism), Graduate
School of Comprehensive Human Sciences, University of Tsukuba, Japan 2 Center
for Tsukuba Advanced Research Alliance, University of Tsukuba, Japan 3 ... Cited by 8 - Related articles - View as HTML - BL Direct - All 6 versions
A Takahashi, K Motomura, T Kato, T … - Diabetes, 2005 - Am Diabetes Assoc Influx of excess fatty acids and the resultant accumulation of intracellular
triglycerides are linked to impaired insulin secretion and action in the
pathogenesis of type 2 diabetes. Sterol regulatory element-binding protein ( ... Cited by 43 - Related articles - All 5 versions
M Ishikawa, F Okajima, N Inoue, K Motomura … - Journal of atherosclerosis and thrombosis, 2006 - sinoas.com Statins are specific and potent competitive inhib- itors of
3-hydroxy-3methylglutaryl coenzyme A (HMG- CoA) reductase and are widely used as
plasma choles- terol-lowering drugs to prevent the development and ... Cited by 8 - Related articles - BL Direct - All 3 versions
KH Hellemans, JC Hannaert, B Denys, KR …, 2009 - pubmedcentral.nih.gov Chronically elevated levels of fatty acids-FA can cause beta cell death in
vitro. Beta cells vary in their individual susceptibility to FA-toxicity. Rat
beta cells were previously shown to better resist FA-toxicity in conditions ... Related articles - All 4 versions
Y Iwasaki, H Iwasaki, S Yatoh, M Ishikawa, … - Biochemical and Biophysical Research …, 2009 - Elsevier Transgenic mice expressing nuclear sterol regulatory element-binding protein-1a
under the control of the insulin promoter were generated to determine the role
of SREBP-1a in pancreatic β-cells. Only low expressors could be ... Related articles - All 2 versions
S Shao, Z Fang, X Yu, M Zhang - Biochemical and Biophysical Research …, 2009 - Elsevier GSIS, the most important function of pancreatic beta cell, is essential for
maintaining the glucose homeostasis. Transcription factors are known to control
different biological processes such as differentiation, proliferation and ... Related articles - All 2 versions
