- ►diabetesjournals.org A Fukuda, Y Kawaguchi, K Furuyama, S Kodama, M … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—Most pancreatic endocrine cells derive from Ptf1a-expressing progenitor cells.
In humans, nonsense mutations in Ptf1a have recently been identified as a cause of permanent
neonatal diabetes associated with pancreatic agenesis. The death of Ptf1a-null mice ... Cited by 2 - Related articles - All 4 versions
E Tweedie, I Artner, L Crawford, G Poffenberger, B … - Diabetes, 2006 - Am Diabetes Assoc The Onecut homeodomain transcription factor hepatic nuclear factor 6 (Hnf6) is necessary for
proper development of islet β-cells. Hnf6 is initially expressed throughout the pancreatic epithelium
but is downregulated in endocrine cells at late gestation and is not expressed in postnatal ... Cited by 4 - Related articles - BL Direct - All 6 versions
ZH Jarikji, S Vanamala, CW Beck, CVE Wright, SD … - Developmental biology, 2007 - Elsevier Determining the functional attributes of pancreatic transcription factors is essential to understand
how the pancreas is specified distinct from other endodermal organs, such as liver, stomach
and duodenum, and to direct the differentiation of other cell types into pancreas. ... Cited by 10 - Related articles - All 4 versions
- ►diabetesjournals.org A Misfeldt… - Diabetes, 2008 - Am Diabetes Assoc RESULTS—In control mice, PPx stimulated β-cell proliferation and neogenesis and upregulated
Foxm1 and several of its known targets (Plk1, Cenp-a, Birc5/Survivin, and Ccnb1) in islets. Within
1 week post-PPx, control mice underwent significant regeneration of β-cell mass, and ... Cited by 4 - Related articles - All 3 versions
Y Wang, H Feng, C Bi, L Zhu, JW Pollard, B Chen - FEBS letters, 2007 - Elsevier We report that glycogen synthase kinase (GSK)-3β is phosphorylated at ser9 and inactivated
in uterine epithelial cells from E 2 -treated cyclin D1 null mutant mice. Simultaneous administration
of P 4 together with E 2 blocked this effect. Pharmacological inhibition of GSK-3β activity ... Cited by 4 - Related articles - All 6 versions
M Öström, KA Loffler, S Edfalk, L Selander, U Dahl, … - PLoS One, 2008 - pubmedcentral.nih.gov The identification of secreted factors that can selectively stimulate the generation of insulin producing
β-cells from stem and/or progenitor cells represent a significant step in the development of stem
cell-based β-cell replacement therapy. By elucidating the molecular mechanisms that ... Cited by 4 - Related articles - All 7 versions
Y Jiang, W Nishimura, D Devor-Henneman, D Kusewitt, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Selective deletion of survivin in pancreatic endocrine cells in the mouse had no
discernible effects during embryogenesis but was associated with striking decreases in β-cell
number after birth, leading to hyperglycemia and early-onset diabetes by 4 weeks of age. ... Cited by 4 - Related articles - All 5 versions
P Dong, E Provost, SD Leach, DYR … - Genes & Development, 2008 - genesdev.cshlp.org The mechanisms regulating pancreatic endocrine versus exocrine fate are not well defined. By
analyzing the effects of Ptf1a partial loss of function, we uncovered novel roles for this transcription
factor in determining pancreatic fates. In a newly identified hypomorphic ptf1a mutant, ... Cited by 4 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org L Marzban, A Tomas, TC Becker, L Rosenberg, J … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Thioflavine S–positive amyloid deposits were clearly present after 10 days of
culture. Transduction with Ad-hProIAPP-siRNA reduced proIAPP expression by 75% compared
with nontransduced islets as assessed by Western blot analysis of islet lysates 4 days ... Cited by 5 - Related articles - All 3 versions
S Zertal-Zidani, A Bounacer, R Scharfmann - Diabetologia, 2007 - Springer Abstract Aims/hypothesis Epithelium–mesenchyme interactions play a major role in pancreas
development. Recently, we demonstrated that embryonic pancreatic mesenchyme en- hanced
progenitor cell proliferation but inhibited endocrine cell differentiation. Here, we ... Cited by 5 - Related articles - BL Direct - All 4 versions
