M Kebede, T Alquier, MG Latour, M Semache, … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—The G-protein–coupled receptor GPR40 is expressed in pancreatic
β-cells and is activated by long-chain fatty acids. Gene deletion studies have
shown that GPR40 mediates, at least in part, fatty acid–amplification of ... Cited by 13 - Related articles - All 4 versions
- ►diabetesjournals.org CP Tan, Y Feng, YP Zhou, GJ Eiermann, A … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE— Acute activation of G protein–coupled receptor 40 (GPR40) by free
fatty acids (FFAs) or synthetic GPR40 agonists enhances insulin secretion.
However, it is still a matter of debate whether activation of GPR40 would ... Cited by 17 - Related articles - All 5 versions
H Lan, LM Hoos, L Liu, G Tetzloff, W Hu, SJ … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—FFAR1/GPR40 is a G-protein–coupled receptor expressed
predominantly in pancreatic islets mediating free fatty acid–induced insulin
secretion. However, the physiological role of FFAR1 remains controversial. ... Cited by 9 - Related articles - All 5 versions
- ►diabetesjournals.org K Nagasumi, R Esaki, K Iwachidow, Y … - Diabetes, 2009 - Am Diabetes Assoc RESULTS In comparison with nontransgenic littermates, hGPR40 transgenic mice
exhibited improved oral glucose tolerance with an increase in insulin secretion.
Although islet morphologic analysis showed no obvious differences between ... Cited by 8 - Related articles - All 4 versions
E Flodgren, B Olde, S Meidute-Abaraviciene, … - Biochemical and Biophysical Research …, 2007 - Elsevier The free fatty acid receptor, GPR40, has been coupled with insulin secretion via
its expression in pancreatic β-cells. However, the role of GPR40 in the release
of glucagon has not been studied and previous attempts to identify the ... Cited by 15 - Related articles - All 5 versions
S Schnell, M Schaefer, C Schöfl - Molecular and cellular endocrinology, 2007 - Elsevier Free fatty acids (FFA) cause a rise in cytosolic free Ca 2+ ([Ca 2+ ] i ) and
stimulate insulin release from pancreatic β-cells. The G-protein coupled
receptor GPR40 can be activated by medium- and long-chain FFA. We ... Cited by 24 - Related articles - All 3 versions
- ►endojournals.org R Vettor, M Granzotto, D De Stefani, E Trevellin … - Journal of Clinical Endocrinology & Metabolism, 2008 - Endocrine Soc Study Design and Results: For in vivo studies, we screened 734 subjects for the
coding region of GPR40 and identified a new single-nucleotide mutation
(Gly180Ser). The mean allele frequency was 0.75%, which progressively ... Cited by 5 - Related articles - All 4 versions
R Brownlie, R Mayers, J Pierce, A Marley, D … - Biochemical Society Transactions, 2008 - biochemsoctrans.org GPR40 (G-protein-coupled receptor 40) has been shown to be a physiologically
relevant receptor for long-chain fatty acids. It is a family A G-protein-coupled
receptor highly expressed in the β-cell where it increases insulin ... Cited by 5 - Related articles - Cached - All 4 versions
MG Latour, T Alquier, E Oseid, C Tremblay, TL … - Diabetes, 2007 - Am Diabetes Assoc Long-chain fatty acids amplify insulin secretion from the pancreatic β-cell.
The G-protein–coupled receptor GPR40 is specifically expressed in β-cells and
is activated by fatty acids; however, its role in acute regulation of ... Cited by 47 - Related articles - BL Direct - All 6 versions
S Edfalk, P Steneberg, H Edlund - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—The G-protein–coupled receptor Gpr40 is expressed in β-cells
where it contributes to free fatty acid (FFA) enhancement of glucose-stimulated
insulin secretion (1–4). However, other sites of Gpr40 expression, ... Cited by 16 - Related articles - All 4 versions
