N Grarup, G Andersen, NT Krarup, A Albrechtsen, O … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— Homozygous carriers of the minor diabetes risk G-allele of the CDC123/CAMK1D
rs12779790 showed an 18% decrease in insulinogenic index (95% CI 10–27%; P = 4 × 10
−5 ), an 18% decrease in corrected insulin response (CIR) (8.1–29%; P = 4 × 10 −4 ), and ... Cited by 16 - Related articles - All 6 versions
H Staiger, F Machicao, K Kantartzis, SA Schäfer, K … - PLoS ONE, 2008 - pubmedcentral.nih.gov Genome-wide association (GWA) studies identified a series of novel type 2 diabetes risk
loci. Most of them were subsequently demonstrated to affect insulin secretion of pancreatic
β-cells. Very recently, a meta-analysis of GWA data revealed nine additional risk loci with ... Cited by 10 - Related articles - All 6 versions
DK Sanghera, L Been, L Ortega, GS Wander, NK … - Journal of Human …, 2009 - nature.com A recent meta-analysis on three genome-wide association (GWA) scans identified six loci
(NOTCH2, THADA, ADAMTS9, JAZF1, CDC123/CAMKID and TSPAN8/LGRS) highly associated
with type II diabetes (T2D) in Caucasians. This investigation seeks to confirm this ... Cited by 3 - Related articles - All 3 versions
H Lango, CNA Palmer, AD Morris, E Zeggini, AT … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVES—Genome-wide association studies have dramatically increased the number of
common genetic variants that are robustly associated with type 2 diabetes. A possible clinical
use of this information is to identify individuals at high risk of developing the disease, so ... Cited by 28 - Related articles - All 5 versions
MD Niels Grarup, G Andersen, NTK PhD, AA MB, OS … - Am Diabetes Assoc Page 1. Association testing of novel type 2 diabetes risk-alleles in the JAZF1, CDC123/CAMK1D,
TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity and obesity
in a population-based sample of 4,516 glucose-tolerant middle-aged Danes ... Related articles
Y Wu, H Li, RJF Loos, Z Yu, X Ye, L Chen, A Pan, FB … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— We confirmed the associations between type 2 diabetes and variants near CDKAL1
(odds ratio 1.49 [95% CI 1.27–1.75]; P = 8.91 × 10 −7 ) and CDKN2A/B (1.31 [1.12–1.54]; P =
1.0 × 10 −3 ). We observed significant association of SNPs in IGF2BP2 (1.17 [1.03–1.32]; ... Cited by 28 - Related articles - All 5 versions
- ►diabetesjournals.org [PDF] N Grarup, CS Rose, EA Andersson, G Andersen, AL … - Diabetes, 2007 - Am Diabetes Assoc Page 1. Studies of Association of Variants Near the HHEX, CDKN2A/B, and IGF2BP2
Genes With Type 2 Diabetes and Impaired Insulin Release in 10,705 Danish Subjects
Validation and Extension of Genome-Wide Association Studies ... Cited by 60 - Related articles - BL Direct - All 3 versions
MJ Groenewoud, JM Dekker, A Fritsche, E Reiling, G … - Diabetologia, 2008 - Springer Abstract Aims/hypothesis Genome-wide association studies have recently identified novel type
2 diabetes susceptibility gene regions. We assessed the effects of six of these regions on insulin
secretion as determined by a hyperglycaemic clamp. Methods Variants of the HHEX/IDE, ... Cited by 6 - Related articles - All 3 versions
- ►diabetesjournals.org [PDF] ND Palmer, MO Goodarzi, CD Langefeld, J Ziegler, JM … - Diabetes, 2008 - Am Diabetes Assoc Nicholette D. Palmer, 1,2 Mark O. Goodarzi, 3 Carl D. Langefeld, 4 Julie Ziegler, 4 Jill M.
Norris, 5 ... Steven M. Haffner, 6 Michael Bryer-Ash, 7,8 Richard N. Bergman, 9 Lynne E.
Wagenknecht, 4 ... Kent D. Taylor, 3 Jerome I. Rotter, 3 and Donald W. Bowden 1,2,10 Cited by 26 - Related articles - BL Direct - All 4 versions
T Sparsø, G Andersen, A Albrechtsen, T Jørgensen, K … - Diabetologia, 2008 - Springer Abstract Aim/hypothesis Recently, variants in WFS1 have been shown to be associated with
type 2 diabetes. We aimed to examine metabolic risk phenotypes of WFS1 variants in
glucose- tolerant people and in individuals with abnormal glucose regulation. Methods ... Cited by 7 - Related articles - All 3 versions
