H Wang, LA Knaub, DR Jensen, D Young Jung … - Diabetes, 2009 - Am Diabetes Assoc RESULTS—Nine-week-old SMLPL −/− mice showed no differences in body weight,
fat mass, or whole-body insulin sensitivity, but older SMLPL −/− mice had
greater weight gain and whole-body insulin resistance. High-fat diet ... Cited by 12 - Related articles - All 5 versions
MJ Watt, EW Kraegen - Diabetes, 2009 - Am Diabetes Assoc The evidence is now compelling that an excess supply of fatty acids, beyond that
required for energy needs, is a cause of muscle insulin resistance.
Intramyocellular triglyceride accumulation is a marker of excess fatty acid ... Cited by 1 - Related articles - All 3 versions
H Wang, RH Eckel - American Journal of Physiology- Endocrinology And …, 2009 - Am Physiological Soc Lipoprotein lipase (LPL) is a multifunctional enzyme produced by many tissues,
including adipose tissue, cardiac and skeletal muscle, islets, and macrophages.
LPL is the rate-limiting enzyme for the hydrolysis of the triglyceride (TG) ... Cited by 3 - Related articles - All 4 versions
- ►pnas.org CS Choi, DE Befroy, R Codella, S Kim, RM … - Proceedings of the National Academy of Sciences, 2008 - National Acad Sciences Peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α has been
shown to play critical roles in regulating mitochondria biogenesis, respiration,
and muscle oxidative phenotype. Furthermore, reductions in the expression ... Cited by 16 - Related articles - All 7 versions
AST Bickerton, R Roberts, BA Fielding, H … - Diabetologia, 2008 - Springer Abstract Aims/hypothesis Increased NEFA production and concen- trations may
underlie insulin resistance. We examined systemic and adipose tissue NEFA
metabolism in insulin- resistant overweight men (BMI 25–35 kg/m2). ... Cited by 8 - Related articles - All 3 versions
- ►diabetesjournals.org K Morino, S Neschen, S Bilz, S Sono, D … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Tg IRS-1 Ser→Ala mice were protected from fat-induced insulin
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최철수 - 대한내분비학회지: 제, 2009 - synapse.koreamed.org 제2형 당뇨병뿐만 아니라 대사증후군 발생의 핵심인자로
생각되고 있는 인슐린 저항성은 생리적 인슐린 농도에서 인
슐린의 작용(인슐린 감수성: Insulin sensitivity)이 저하된 대 ... Related articles - View as HTML - All 2 versions
L Chow, A From, E Seaquist - Metabolism, 2009 - Elsevier The prevalence of type 2 diabetes mellitus (DM2) is increasing precipitously as
a consequence of the aging population and obesity epidemic. Type 2 diabetes
mellitus is characterized by both pancreatic β-cell dysfunction and ... Related articles - All 2 versions
G Sabio, NJ Kennedy, J Cavanagh-Kyros, DY … - Molecular and Cellular Biology, 2009 - Am Soc Microbiol Page 1. Guadalupe Sabio Page 1 Role of muscle JNK1 in obesity-induced insulin
resistance Running Title: Mice with muscle-specific JNK1-deficiency ... Related articles - All 2 versions
AS Sirek, L Liu, M Naples, K Adeli, DS Ng, T … - Endocrinology, 2009 - Endocrine Soc The carbohydrate response element binding protein (ChREBP) has been recognized
as a key controller of hepatic lipogenesis. Whereas the function of ChREBP has
been extensively investigated, mechanisms underlying its transcription ... Related articles
