JS Allen, K Pang, A Skowera, R Ellis, C … - Diabetes, 2009 - Am Diabetes Assoc RESULTS—The balance of blood dendritic cells was profoundly disturbed at
diabetes diagnosis, with a significantly elevated proportion of plasmacytoid and
reduction of myeloid cells compared with control subjects. Dendritic cell ... Cited by 6 - Related articles - All 3 versions
R Tisch, B Wang - Diabetes, 2009 - Am Diabetes Assoc Type 1 diabetes is characterized by T-cell–mediated destruction of
insulin-producing β-cells. Progression of β-cell autoimmunity is
simplistically viewed as a functional imbalance favoring the development of ... Cited by 1 - Related articles - All 3 versions
- ►diabetesjournals.org Y Huang, IJ Fugier-Vivier, T Miller, MJ Elliott, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—We report for the first time that NOD FCs are functionally impaired.
They fail to facilitate engraftment of syngeneic and allogeneic HSCs in vivo and
do not enhance HSC clonogenicity in vitro. NOD FCs contain subpopulations ... Cited by 2 - Related articles - All 5 versions
Y Jin, X Chen, R Podolsky, D Hopkins, LHC … - Clinical Immunology, 2009 - Elsevier It is widely believed that CD4 + CD25 + regulatory T cells (Treg) are defective
in type 1 diabetes (T1D) and other autoimmune diseases. However, this conclusion
is based on the suboptimal in vitro suppression results from very small ... Cited by 2 - Related articles - All 2 versions
[CITATION] von HM (2007) Translational mini-review series on type 1 diabetes: Immune-based …
C Ricordi, BJ Hering, AMJ Shapiro - The Lancet, 2008 - Elsevier Islet transplantation outcomes are likely to improve substantially over the next
3–5 years, as a result of novel immunosuppressive regimens with fewer toxic
effects. Even more far-reaching improvements will emerge from islet ... Cited by 3 - Related articles - All 9 versions
- ►nih.gov Q Li, B Xu, SA Michie, KH Rubins, RD … - Proceedings of the National Academy of Sciences, 2008 - National Acad Sciences With the goal of identifying changes in gene expression in CD4 + T cells during
the development of diabetes in the nonobese diabetic (NOD) mouse, we used DNA
microarrays to analyze gene expression in CD4 + T cells from the pancreatic ... Cited by 4 - Related articles - All 6 versions
- ►jimmunol.org AM Marleau, KL Summers, B Singh - The Journal of Immunology, 2008 - Am Assoc Immnol Despite the pivotal role of dendritic cells (DC) in shaping immunity, little is
known about their functionality in type 1 diabetes. Moreover, due to the paucity
of DC in vivo, functional studies have relied largely upon in ... Cited by 4 - Related articles - All 2 versions
L Chatenoud, JF Bach - Expert Opin. Biol. Ther., 2005 - informahealthcare.com Over the last few years, there has been a re-emergence of the concept of
suppressor/regulatory T cells among the central players of immune mecha- nisms
controlling a wide variety of immune responses from physiological ... Cited by 4 - Related articles - All 4 versions
NE Standifer, EA Burwell, VH Gersuk, CJ … - Clinical Immunology, 2009 - Elsevier The activation threshold for antigen-specific T cell responses is dependent on
the avidity of the trimolecular interaction between TCR, antigen, and MHC. We
compared CD4+ T cell avidities for the diabetes-associated autoantigen ... Related articles - All 2 versions
