YH Van, WH Lee, S Ortiz, MH Lee, HJ Qin, CP … - Diabetes, 2009 - Am Diabetes Assoc RESULTS—Our data demonstrated that ATRA treatment inhibited diabetes in NOD
mice with established insulitis. In addition, it suppressed interferon
(IFN)-γ–producing CD4 + and CD8 + T effector (Teff) cells and expanded T ... Cited by 4 - Related articles - All 3 versions
DR Cavener - Diabetes, 2009 - Am Diabetes Assoc In all cell types of the body, save one, the insulin gene is quiescent and is
ensconced in a compact and protected environment of chromatin. How the insulin
gene is coaxed out of its chromatin slumber in the pancreatic β-cell is ... Cited by 1 - Related articles - All 4 versions
SA Litherland - Diabetes, 2008 - Am Diabetes Assoc Autoimmune type 1 diabetes is caused by an interactive combination of genetic
and environmental factors, most of which remain unknown. Each individual appears
to have a unique combination of these factors that allow for their ... Cited by 1 - Related articles - All 4 versions
Y Zhao, B Lin, R Darflinger, Y Zhang, MJ … - PLoS ONE, 2009 - pubmedcentral.nih.gov Here, we report that treatment of established autoimmune-caused diabetes in NOD
mice with purified autologous CD4 CD62L Tregs co-cultured with human cord blood
stem cells (CB-SC) can eliminate hyperglycemia, promote islet β-cell ... Cited by 2 - Related articles - All 4 versions
E Bonifacio, A Mayr, A Knopff, AG Ziegler - Diabetologia, 2009 - Springer Abstract Aims/hypothesis Thyroid autoimmunity clusters with other endocrine and
non-endocrine forms of autoimmunity. The aim of this study was to determine the
chronological appearance of thyroid autoantibodies in relation to other ... Cited by 1 - Related articles - All 3 versions
P Monti, AK Heninger, E Bonifacio - Current Diabetes Reports, 2009 - Springer Autoreactive T cells play a major role in the patho- genesis of type 1 diabetes
mellitus (T1DM) and are considered a major target of immunomodulatory strategies
aimed at preventing or delaying the disease onset. However, the T-cell ... Cited by 1 - Related articles - All 2 versions
R Tisch, B Wang - Diabetes, 2009 - Am Diabetes Assoc Type 1 diabetes is characterized by T-cell–mediated destruction of
insulin-producing β-cells. Progression of β-cell autoimmunity is
simplistically viewed as a functional imbalance favoring the development of ... Cited by 1 - Related articles - All 3 versions
P Mitchell, B Afzali, G Lombardi, RI Lechler - Current Opinion in Organ Transplantation, 2009 - journals.lww.com Introduction CD4þCD25hi regulatory T cells (Tregs) play a critical role in
maintaining self-tolerance in the periphery. In light of this, these cells are
now considered an important target for generating tolerance to solid organ ... Cited by 1 - Related articles - All 3 versions
RF Vogt Jr, RA Kyle - The New England Journal of Medicine, 2009 - nejm.highwire.org It seems that B cells, the lymphocytes responsible for producing antibodies, are
eager to share their secrets. Their revelations were first uncovered indirectly
in serum through reactions with microbes, cells, and toxins; increases in ... Cited by 1 - Related articles - All 3 versions
C Ionescu-Tirgoviste - Romanian Journal of Internal Medicine, 2007 - 万方数据资源系统 The main beta cell function is that of pre-proinsulin synthesis and of insulin
exocytosis in a regulated manner. After the detachment of a small signal
peptide, the remaining proinsulin molecule is transferred in the ... Cited by 2 - Related articles - BL Direct
