YD Dai, IG Marrero, P Gros, H Zaghouani, LS … - Diabetes, 2009 - Am Diabetes Assoc OBJECTIVE—Efforts to map non–major histocompatibility complex (MHC) genes
causing type 1 diabetes in NOD mice identified Slc11a1, formerly Nramp1, as the
leading candidate gene in the Idd5.2 region. Slc11a1 is a membrane ... Cited by 3 - Related articles - All 3 versions
E Sgouroudis, A Albanese, CA Piccirillo - The Journal of Immunology, 2008 - Am Assoc Immnol Type I diabetes (T1D) susceptibility is inherited through multiple
insulin-dependent diabetes (Idd) genes. NOD.B6 Idd3 congenic mice, introgressed
with an Idd3 allele from T1D-resistant C57BL/6 mice (Idd3 B6 ), show a ... Cited by 6 - Related articles - All 2 versions
- ►jimmunol.org J Irie, B Reck, Y Wu, LS Wicker, S Howlett, … - The Journal of Immunology, 2008 - Am Assoc Immnol NOD.Idd3/5 congenic mice have insulin-dependent diabetes (Idd) regions on
chromosomes 1 (Idd5) and 3 (Idd3) derived from the nondiabetic strains B10 and
B6, respectively. NOD.Idd3/5 mice are almost completely protected from type ... Cited by 5 - Related articles - All 3 versions
- ►jimmunol.org K Hunter, D Rainbow, V Plagnol, JA Todd, LB … - The Journal of Immunology, 2007 - Am Assoc Immnol Two loci, Idd5.1 and Idd5.2, that determine susceptibility to type 1 diabetes
(T1D) in the NOD mouse are on chromosome 1. Idd5.1 is likely accounted for by a
synonymous single nucleotide polymorphism in exon 2 of Ctla4: the ... Cited by 10 - Related articles - All 3 versions
- ►nih.gov CB Stober, S Brode, JK White, JF Popoff, JM … - Infection and Immunity, 2007 - iai.highwire.org Solute carrier family 11 member a1 (Slc11a1; formerly Nramp1) encodes a late
endosomal/lysosomal protein/divalent cation transporter that regulates iron
homeostasis in macrophages. During macrophage activation, Slc11a1 has ... Cited by 12 - Related articles - BL Direct - All 6 versions
RB Pearce - Autoimmunity, 1998 - informahealthcare.com T/f (T lymphocyte fraction) defines a locus that governs the unusually high
fraction of circulating T lymphocytes in the nonobese diabetic (NOD) mouse. We
previously mapped T/f to proximal Chromosome 9 in BCI mice.l'l Here, Tlf ... Cited by 2 - Related articles - BL Direct - All 5 versions
WM Ridgway, LB Peterson, JA Todd, DB … - Advances in Immunology, 2008 - Elsevier Human genome wide association studies (GWAS) have recently identified at least
four new, non-MHC-linked candidate genes or gene regions causing type one
diabetes (T1D), highlighting the need for functional models to investigate ... Cited by 2 - Related articles - All 3 versions
- ►jimmunol.org RJ Mellanby, CH Koonce, A Monti, JM Phillips … - The Journal of Immunology, 2006 - Am Assoc Immnol The invariant (Ii) chain acts as an essential chaperone to promote MHC class II
surface expression, Ag presentation, and selection of CD4 + T cells. We have
examined its role in the development of type 1 diabetes in NOD mice and ... Cited by 2 - Related articles - BL Direct - All 5 versions
CA Lazarski, A Hughson, DK Sojka, DJ Fowell - Immunity, 2008 - Elsevier Regulatory T (Treg) cells are emerging as common components in the development
of immunity to both self and foreign antigen. With their ubiquitous
participation comes the need to regulate the regulators to ensure ... Cited by 2 - Related articles - All 2 versions
- ►jimmunol.org DV Serreze, CM Choisy-Rossi, AE Grier, TM … - The Journal of Immunology, 2008 - Am Assoc Immnol When expressed in NOD, but not C57BL/6 (B6) genetic background mice, the common
class I variants encoded by the H2 g7 MHC haplotype aberrantly lose the ability
to mediate the thymic deletion of autoreactive CD8 + T cells contributing ... Cited by 3 - Related articles - All 2 versions
