J Mangada, T Pearson, MA Brehm, LS Wicker, … - Diabetes, 2009 - Am Diabetes Assoc RESULTS—The frequency of diabetes is reduced in NOD.B6 Idd3 mice and is
virtually absent in NOD.B6/B10 Idd3 Idd5 mice. Islet allograft survival in
NOD.B6 Idd3 mice treated with costimulation blockade is prolonged compared ... Cited by 1 - Related articles - All 4 versions
R Del Rio, R Noubade, M Subramanian, N … - Genes and Immunity, 2008 - nature.com IL-2, a T-cell growth and differentiation factor, plays an important role in
immune homeostasis. Previously, we identified IL2 as a candidate for Aod2, a
quantitative trait locus (QTL) controlling susceptibility to autoimmune ... Cited by 6 - Related articles - BL Direct - All 3 versions
- ►nih.gov [PDF] NA Cacalano, JA Johnston - The American Journal of Human Genetics, 1999 - Elsevier Cytokines control the growth, differentiation, and survival of cells of the
immune system. Since the identification of the genes for the T-cell growth
factor interleukin-2 (IL-2) and its heterotrimeric receptor (IL-2R), the ... Cited by 4 - Related articles - BL Direct - All 5 versions
[CITATION] Shared, distinct and opposing genetic factors in type 1 diabetes and celiac disease
L Wang, Y Kametani, I Katano, S Habu - Biochemical and Biophysical Research …, 2005 - Elsevier The IL-2 gene expression is highly T-cell specific in an activation-dependent
manner. However, little is known about how T-cell specific expression is
regulated, although related transcription factors have been identified. To ... Cited by 5 - Related articles - All 4 versions
AC Anderson, R Chandwaskar, DH Lee, VK … - The Journal of Immunology, 2008 - Am Assoc Immnol The Idd3 genetic interval confers protection against multiple autoimmune
diseases, including type 1 diabetes and experimental autoimmune
encephalomyelitis. The favored candidate gene in this interval is Il2, ... Cited by 6 - Related articles - All 2 versions
S Liu, H Wang, Y Jin, R Podolsky, MV Reddy, … - Human Molecular Genetics, 2009 - Oxford Univ Press Genome-wide association (GWA) studies revealed a number of single nucleotide
polymorphisms (SNPs) significantly associated with type 1 diabetes (T1D). In an
attempt to confirm some of these candidate associations, we genotyped 2046 ... Cited by 7 - Related articles - All 3 versions
A Liston, OM Siggs, CC Goodnow - Immunology and cell biology, 2007 - nature.com Genetic variants of interleukin 2 (IL-2) and its receptor are associated with
murine and human susceptibility to Type 1 diabetes, yet the role of IL-2 in
controlling pancreatic islet-reactive T cells is unknown. Here, we develop ... Cited by 8 - Related articles - All 4 versions
FW Velten, F Rambow, P Metharom, S Goerdt - Molecular immunology, 2007 - Elsevier Although standardized protocols are widely used for the generation of
monocyte-derived immunostimulatory dendritic cells (DC ims ), the inducibility
of Th1 cells by DC ims may considerably differ. As a measure for the ... Cited by 9 - Related articles - All 3 versions
- ►hematologylibrary.org MA Brehm, J Mangada, TG Markees, T Pearson … - Blood, 2007 - bloodjournal.hematologylibrary.org Allograft transplantation requires chronic immunosuppression, but there is no
effective strategy to evaluate the long-term maintenance of immunosuppression
other than assessment of graft function. The ability to monitor naive ... Cited by 10 - Related articles - BL Direct - All 8 versions
