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Scholar Results 1 - 10 of about 101 related to Edgerton: Inhibition of Dipeptidyl Peptidase-4 by Vildagliptin During Glucagon-Like Peptide.... (0.11 sec) 

Inhibition of Dipeptidyl Peptidase-4 by Vildagliptin During Glucagon-Like Peptide 1 …


DS Edgerton, K Johnson, DW Neal, M Scott, … - Diabetes, 2009 - Am Diabetes Assoc
RESULTS—Vildagliptin fully inhibited DPP-4 over the 4-h experimental period.
GLP-1 concentrations were increased in the vildagliptin-treated group (50 ± 3
vs. 85 ± 7 pmol/l in the portal vein in control and vildagliptin-treated ...
Related articles - All 3 versions

Relationship between changes in GIP concentrations and changes in insulin and C-peptide …


PH Groop, L Groop, KJ Tötterman, F Fyhrquist - Scandinavian Journal of Clinical & Laboratory …, 1986 - informahealthcare.com
Groop PH, Groop L, Totterman KJ, Fyhrquist F. Relationship between changes in
GIP concentrations and changes in insulin and C-peptide concentrations after
guar gum therapy. Scand J Clin Lab Invest 1986; 46: 505-510.
Cited by 6 - Related articles - All 5 versions

Exenatide can reduce glucose independent of islet hormones or gastric emptying

- physiology.org
V Ionut, D Zheng, D Stefanovski, RN Bergman - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc
Exenatide is a long-acting glucagon-like peptide-1 (GLP-1) mimetic used in the
treatment of type 2 diabetes. There is increasing evidence that GLP-1 can
influence glycemia not only via pancreatic (insulinotropic and glucagon ...
Cited by 7 - Related articles - All 4 versions

Reduction of hepatic insulin clearance after oral glucose ingestion is not mediated by …

- physiology.org
JJ Meier, JJ Holst, WE Schmidt, MA Nauck - American Journal of Physiology- Endocrinology And …, 2007 - Am Physiological Soc
Changes in hepatic insulin clearance can occur after oral glucose or meal
ingestion. This has been attributed to the secretion and action of gastric
inhibitory polypeptide (GIP) and glucagon-like peptide (GLP)–1. Given the ...
Cited by 7 - Related articles - BL Direct - All 5 versions

Intraportal GLP-1 infusion increases nonhepatic glucose utilization without changing …

- physiology.org
K Johnson, DS Edgerton, T Rodewald, M Scott … - American Journal of Physiology- Endocrinology And …, 2007 - Am Physiological Soc
After a meal, glucagon-like peptide-1 (GLP-1) levels in the hepatic portal vein
are elevated and are twice those in peripheral blood. The aim of this study was
to determine whether any of GLP-1's acute metabolic effects are initiated ...
Cited by 8 - Related articles - BL Direct - All 3 versions

Mechanism of action of exenatide to reduce postprandial hyperglycemia in type 2 diabetes

- physiology.org
A Cervera, E Wajcberg, A Sriwijitkamol, M … - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc
We examined the contributions of insulin secretion, glucagon suppression,
splanchnic and peripheral glucose metabolism, and delayed gastric emptying to
the attenuation of postprandial hyperglycemia during intravenous exenatide ...
Cited by 10 - Related articles - BL Direct - All 3 versions

Role of a negative arterial-portal venous glucose gradient in the postexercise state

- physiology.org
P Galassetti, Y Koyama, RH Coker, DB Lacy, … - American Journal of Physiology- Endocrinology And …, 1999 - Am Physiological Soc
Prior exercise stimulates muscle and liver glucose uptake. A negative
arterial-portal venous glucose gradient (a-pv grad) stimulates resting net
hepatic glucose uptake (NHGU) but reduces muscle glucose uptake. This study ...
Cited by 9 - Related articles - All 3 versions

Hyperinsulinemia compensates for infection-induced impairment in net hepatic glucose …

- physiology.org
CM Donmoyer, SS Chen, SA Hande, DB Lacy, … - American Journal of Physiology- Endocrinology And …, 2000 - Am Physiological Soc
In animals receiving total parenteral nutrition (TPN), infection impairs net
hepatic glucose uptake (NHGU) by 40% and induces mild hyperinsulinemia. In the
normal animal, the majority of the glucose taken up by the liver is ...
Cited by 9 - Related articles - BL Direct - All 3 versions

Reduced insulin clearance contributes to the increased insulin levels after administration of …


B Ahren, K Thomaseth, G Pacini - Diabetologia, 2005 - Springer
Abstract Aims/hypothesis: Glucagon-like peptide-1 (GLP-1) is known to be a
potent stimulator of insulin secretion. How- ever, whether GLP-1 also affects
insulin clearance is not known. To explore this, we developed a technique ...
Cited by 10 - Related articles - BL Direct - All 3 versions

Intraportally delivered GLP-1, in the presence of hyperglycemia induced via peripheral …

- physiology.org
K Johnson, DS Edgerton, T Rodewald, M Scott … - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc
After a meal, glucagon-like peptide-1 (GLP-1) and glucose levels are
significantly greater in the hepatic portal vein than in the artery. We have
previously reported that, in the presence of intraportal glucose delivery, ...
Cited by 4 - Related articles - BL Direct - All 4 versions


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