- ►uky.edu [PDF] J Xu, DJ Lloyd, C Hale, S Stanislaus, M Chen, … - Diabetes, 2009 - Am Diabetes Assoc RESULTS—FGF21 dose dependently reduced body weight and whole-body fat mass in
DIO mice due to marked increases in total energy expenditure and physical
activity levels. FGF21 also reduced blood glucose, insulin, and lipid ... Cited by 15 - Related articles - All 5 versions
T Coskun, HA Bina, MA Schneider, JD Dunbar … - Endocrinology, 2008 - Endocrine Soc Fibroblast growth factor 21 (FGF21) is a metabolic regulator that provides
efficient and durable glycemic and lipid control in various animal models.
However, its potential to treat obe- sity, a major health concern affecting ... Cited by 15 - Related articles - All 3 versions
A Kharitonenkov, JD Dunbar, HA Bina, S … - Journal of cellular physiology, 2008 - interscience.wiley.com Fibroblast growth factor-21 (FGF-21) is a metabolic regulator that can influence
glucose and lipid control in diabetic rodents and primates. We demonstrate that
Klotho is an integral part of an activated FGF-21- Klotho-FGF receptor ... Cited by 26 - Related articles - BL Direct - All 2 versions
Y Izumiya, HA Bina, N Ouchi, Y Akasaki, A … - FEBS letters, 2008 - Elsevier Fibroblast growth factor-21 (FGF21) functions as a metabolic regulator. The
FGF21 transcript is reported to be abundantly expressed in liver, but little is
known about the regulation of FGF21 expression in other tissues. In this ... Cited by 15 - Related articles - All 4 versions
P Arner, A Pettersson, PJ Mitchell, JD Dunbar … - FEBS letters, 2008 - Elsevier Fibroblast growth factor 21 (FGF21) is active in murine adipocytes and has
beneficial metabolic effects in animal models of type 2 diabetes mellitus. We
assessed whether FGF21 influences lipolysis in human adipocytes and 3T3-L1 ... Cited by 22 - Related articles - All 12 versions
- ►aspetjournals.org ES Muise, B Azzolina, DW Kuo, M El- … - Molecular Pharmacology, 2008 - ASPET Adipose tissue is a metabolically responsive endocrine organ that secretes a
myriad of adipokines. Antidiabetic drugs such as peroxisome
proliferator-activated receptor (PPAR) agonists target adipose tissue gene ... Cited by 10 - Related articles - All 3 versions
- ►endojournals.org M Suzuki, Y Uehara, K Motomura-Matsuzaka, … - Molecular Endocrinology, 2008 - Endocrine Soc Fibroblast growth factor (FGF) 21, a structural relative of FGF23 that regulates
phosphate homeostasis, is a regulator of insulin-independent glucose transport
in adipocytes and plays a role in the regulation of body weight. It also ... Cited by 22 - Related articles - BL Direct - All 3 versions
X Zhang, DCY Yeung, M Karpisek, D Stejskal … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— Serum FGF21 levels in overweight/obese subjects were significantly
higher than in lean individuals. Serum FGF21 correlated positively with
adiposity, fasting insulin, and triglycerides but negatively with HDL ... Cited by 25 - Related articles - BL Direct - All 4 versions
- ►nih.gov H Wang, L Qiang, SR Farmer - Molecular and Cellular Biology, 2008 - Am Soc Microbiol Peroxisome proliferator-activated receptor (PPAR ) activity is regulated through
association with ligands that include the thiazolidinedione class of
antidiabetic drugs, as well as derivatives of polyunsaturated fatty acids. ... Cited by 20 - Related articles - BL Direct - All 6 versions
C Gälman, T Lundåsen, A Kharitonenkov, HA … - Cell Metabolism, 2008 - Elsevier FGF21 is a critical metabolic regulator, pivotal for fasting adaptation and
directly regulated by PPARα in rodents. However, the physiological role of
FGF21 in man is not yet defined and was investigated in our study. Serum ... Cited by 17 - Related articles - All 4 versions
