SFA Grant, HQ Qu, JP Bradfield, L Marchand, CE Kim, … - Diabetes, 2009 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—From our existing datasets, we selected 982 markers
with P < 0.05 in both GWA cohorts. Genotyping these in an independent set of 636 nuclear families
with 974 affected offspring revealed 75 markers that also had P < 0.05 in this third cohort. ... Cited by 7 - Related articles - All 3 versions
F Diabetes - medscape.com The recent development of high-throughput single nucleotide polymorphism (SNP) genotyping
array technologies has enabled us [3] and others [4] to perform high-density genome-wide association
(GWA) studies in search of the remaining type 1 diabetes loci. We recently reported the ... Related articles - All 5 versions
- ►diabetesjournals.org H Hakonarson, HQ Qu, JP Bradfield, L Marchand, CE … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—In stage 1 of our genome-wide association (GWA) study for type 1 diabetes, one
locus at 16p13 was detected (P = 1.03 × 10 −10 ) and confirmed in two additional cohorts. Here
we describe the results of testing, in these additional cohorts, 23 loci that were next in ... Cited by 20 - Related articles - BL Direct - All 4 versions
P Concannon, S Onengut-Gumuscu, JA Todd, DJ … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— Three of the SNPs most strongly associated with type 1 diabetes localized to previously
identified type 1 diabetes risk loci: INS, IFIH1, and KIAA0350. A fourth strongly associated
SNP, rs876498 (P = 1.0 × 10 −4 ), occurred in the sixth intron of the UBASH3A locus at ... Cited by 16 - Related articles - All 6 versions
H Hakonarson - The Future of Genomic Medicine II The Future of … - stsiweb.org Advances in Understanding Chronic Illness: Pediatric Diseases Hakon Hakonarson, MD,
Ph. D. Director, Center for Applied Genomics Department of Pediatrics & Division of Genetics
The Joseph Stokes Jr. Research Institute The Children's Hospital of Philadelphia ... Related articles - View as HTML
HQ Qu, SFA Grant, JP Bradfield, C Kim, E … - British Medical …, 2009 - jmg.bmj.com Methods: We analysed data from two sources: (1) The previously published second stage of
our study, with a total sample size of the two stages consisting of 1046 Canadian case–parent
trios and 538 multiplex families with 929 affected offspring from the Type 1 Diabetes ... Related articles - All 3 versions
SFA Grant, H Hakonarson - Current Diabetes Reports, 2009 - Springer Type 1 diabetes (T1D) is a chronic disease that typically manifests itself in childhood through
the autoimmune destruction of pancreatic β cells, resulting in a lack of production of insulin. T1D
is a multifactorial disease with a strong genetic component that is thought to interact with ... Related articles - All 2 versions
H Hakonarson, SFA Grant - Seminars in Immunology, 2009 - Elsevier Genome-wide association studies have delivered on the promise of uncovering genetic determinants
of complex disease. In this review, we provide a summary of recent advances in the identification
of multiple variants associated with autoimmune-mediated disorders; specifically type 1 ... Related articles - All 2 versions
Z Wei, W Sun, K Wang, H Hakonarson - Bioinformatics, 2009 - Oxford Univ Press Results: We propose to model the linear block dependency in the SNP data using hidden Markov
models (HMMs). A compound decision–theoretic framework for testing HMM-dependent hypotheses
is developed. We propose a powerful data-driven procedure [pooled local index of ... Related articles - All 3 versions
KN Lazaridis, GM Petersen - Clinical Gastroenterology and Hepatology, 2005 - Elsevier Medical science is on the threshold of unparalleled progress as a result of the advent of genomics
and related disciplines. Human genomics, the study of structure, function, and interactions of
all genes in the human genome, promises to improve the diagnosis, treatment, and ... Cited by 7 - Related articles - All 10 versions
