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Scholar Results 1 - 10 of about 101 related to Regazzetti: Hypoxia decreases insulin signaling pathways in adipocytes. (0.09 sec) 

Hypoxia decreases insulin signaling pathways in adipocytes


C Regazzetti, P Peraldi, T Grémeaux, R Najem- … - Diabetes, 2009 - Am Diabetes Assoc
RESULTS—In both human and murine adipocytes, hypoxia inhibits insulin signaling as revealed
by a decrease in the phosphorylation of insulin receptor. In 3T3-L1 adipocytes, this inhibition
of insulin receptor phosphorylation is followed by a decrease in the phosphorylation state ...
Cited by 9 - Related articles - All 4 versions

Skin microcirculatory dysfunction is already present in normoglycemic subjects with …


LG Kraemer-Aguiar, CM Laflor, E Bouskela - Metabolism, 2008 - Elsevier
The role of microcirculatory dysfunction (MD) in metabolic and cardiovascular diseases is not
well established. Considering that metabolic syndrome (MS) is an independent risk factor and
diabetic patients have microangiopathy, our aim was to investigate if normoglycemic ...
Cited by 4 - Related articles - All 9 versions

Release in vitro of adipsin, vascular cell adhesion molecule 1, angiotensin 1– …


JN Fain, AS Nesbit, FF Sudlow, P Cheema, JM Peeples … - Metabolism, 2007 - Elsevier
The relative release in vitro of adipsin, vascular cell adhesion molecule (VCAM) 1, angiotensin
1–converting enzyme (ACE), and soluble tumor necrosis factor α receptor 2 (sTNFR2) by explants
of human omental and subcutaneous adipose tissue as well as the nonfat cell fractions ...
Cited by 6 - Related articles - All 11 versions

[CITATION] RG IJ, de Vries G, Stehouwer CD. Impaired microvascular function in obesity: …


RT de Jongh, EH Serne - Circulation, 2004
Cited by 8 - Related articles

Impaired endothelium-dependent vasodilation in overweight and obese adult …

- physiology.org
GP Van Guilder, BL Stauffer, JJ Greiner, … - American Journal of …, 2008 - Am Physiological Soc
Muscarinic receptor agonists have primarily been used to characterize endothelium-dependent
vasodilator dysfunction with overweight/obesity. Reliance on a single class of agonist,
however, yields limited, and potentially misleading, information regarding endothelial ...
Cited by 7 - Related articles - BL Direct - All 3 versions

Hypoxia induces leptin gene expression and secretion in human preadipocytes: …

- endocrinology-journals.org
B Wang, IS Wood, P Trayhurn - Journal of Endocrinology, 2008 - Soc Endocrinology
The effect of hypoxia on the expression and secretion of major adipokines by human preadipocytes
has been examined. Hypoxia (1% O 2 ) led to an increase in the HIF-1 transcription factor subunit
in cultured preadipocytes, as did incubation with the hypoxia mimetic CoCl 2 . Leptin ...
Cited by 9 - Related articles - All 4 versions

Inflammation, Insulin Resistance, and Type 2 Diabetes: Back to the Future?


WT Cefalu - Diabetes, 2009 - Am Diabetes Assoc
In this issue of Diabetes, two articles highlight the emergence of inflammation's contribution to
insulin resistance and to chronic diseases in humans. The common feature in each article is
the inflammation–obesity–insulin resistance connection, but each article approaches the ...
Related articles - All 3 versions

A cross-sectional relationship between vital capacity and metabolic syndrome and …


E Oda, R Kawai - Environmental Health and Preventive Medicine, 2009 - Springer
Abstract Objectives A lower vital capacity (VC) has been reported to be an independent predictor
of diabetes in Western countries. The aim of this study was to examine the rela- tionships between
VC and diabetes and between VC and metabolic syndrome (MS) in Japanese ...
Related articles - All 2 versions

Alterações metabólicas associadas à obesidade: o papel da disfunção da …

- scielo.br
NR Villela… - Arq Bras Endocrinol Metab - SciELO Brasil
Associated with elevated risk of cardiovascular events and cancer, obesity is a worldwide problem
affecting developed and developing countries. Microcirculatory vessels, represented by
arterioles, capillaries and venules (mean internal diameter < 100 µm), are the place ...
Related articles - Cached - All 2 versions

Breathing Room: The (Un) Natural History of Adipose Microhypoxia and Insulin …


KD Copps, MF White - Diabetes, 2009 - Am Diabetes Assoc
The basis for the clustering of obesity with insulin resistance, type 2 diabetes, and related pathologies
of the metabolic syndrome is complex but involves altered metabolic function and substrate flow
both within and between insulin-responsive fat, muscle, and liver tissues (1,2). Since the ...
Related articles - All 4 versions


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