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Scholar Results 1 - 10 of about 101 related to Lee: Overexpression of SIRT1 Protects Pancreatic {beta}-Cells Against Cytokine Toxicity by.... (0.09 sec) 

Overexpression of SIRT1 Protects Pancreatic {beta}-Cells Against Cytokine Toxicity by …

- diabetesjournals.org
JH Lee, MY Song, EK Song, EK Kim, WS Moon … - Diabetes, 2009 - Am Diabetes Assoc
RESULTS—Treatment of RIN cells with cytokines induced cell damage, and this
damage was well correlated with the expression of the inducible form of nitric
oxide (NO) synthase (iNOS) and NO production. However, SIRT1 overexpression ...
Cited by 9 - Related articles - All 4 versions

JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through …


N Lv, EK Kim, MY Song, HN Choi, WS Moon, … - Experimental cell research, 2009 - Elsevier
JANEX-1/WHI-P131, a selective Janus kinase 3 (JAK3) inhibitor, has been shown to
delay the onset of diabetes in the NOD mouse model. However, the molecular
mechanism by which JANEX-1 protects pancreatic β-cells is unknown. In the ...
Cited by 1 - Related articles - All 3 versions

[CITATION] Overexpression of SIRT1protects pancreatic h-cells against cytokine toxicity by suppressing …


JH Lee, MY Song, EK Song… - Diabetes, 2009
Cited by 2 - Related articles

Guggulsterone, a plant sterol, inhibits NF-κB activation and protects pancreatic β cells from …


N Lv, MY Song, EK Kim, JW Park, KB Kwon, … - Molecular and cellular endocrinology, 2008 - Elsevier
Guggulsterone has been used to treat hyperlipidemia, arthritis, and obesity.
Although its anti-inflammatory and anti-hyperlipidemic effects have been well
documented, the effect of guggulsterone on pancreatic β cells is unknown. ...
Cited by 3 - Related articles - All 4 versions

Genistein protects pancreatic β cells against cytokine-mediated toxicity


EK Kim, KB Kwon, MY Song, SW Seo, SJ Park, … - Molecular and cellular endocrinology, 2007 - Elsevier
In the past few decades, the use of genistein as an anti-inflammatory agent has
gained much attention. Our current study focuses on the preventive effects of
genistein on cytokine-induced pancreatic β-cell damage. Treatment of ...
Cited by 8 - Related articles - All 3 versions

Expression of DBC1 and SIRT1 Is Associated with Poor Prognosis of Gastric Carcinoma


EJ Cha, SJ Noh, KS Kwon, CY Kim, BH Park, … - Clinical Cancer Research, 2009 - AACR
Results: Positive expressions of DBC1 and SIRT1 were seen in 62% (109 of 177)
and in 73% (130 of 177) of patients, respectively. Expression of DBC1 was
significantly correlated with tumor stage (P = 0.007), lymph node ...
Related articles - All 4 versions

Histone Deacetylase Inhibitors Target Diabetes via Chromatin Remodeling or as Chemical …


MW Lawless, KJ OByrne, SG Gray - Current Diabetes Reviews, 2009 - ingentaconnect.com
Abstract: Globally, obesity and diabetes (particularly type 2 diabetes)
represents a major challenge to world health. De- spite decades of intense
research efforts, the genetic basis involved in diabetes pathogenesis & ...
Related articles - All 2 versions

Metabolic benefits from Sirt1 and Sirt1 activators


N Chaudhary, PT Pfluger - Current Opinion in Clinical Nutrition & Metabolic Care, 2009 - journals.lww.com
Introduction Sirtuins, named after their homology to the Saccharomyces
cerevisiae gene silent information regulation-2 (Sir2), con- stitute a family of
highly conserved nicotinamide adenine dinucleotide (NADþ)-dependent ...
Cited by 1 - Related articles - All 3 versions

Increases in nuclear p65 activation in dystrophic skeletal muscle are secondary to increases …


R Singh, G Millman, E Turin, L Polisiakeiwicz … - Journal of the Neurological Sciences, 2009 - Elsevier
Dystrophin-deficient muscle exhibits substantial increases in nuclear NF-κB
activation. To examine potential mechanisms for this enhanced activation, the
present study employs conventional Western blot techniques to provide the ...
Related articles - All 11 versions

A20 Attenuates Allergic Airway Inflammation in Mice


NI Kang, HY Yoon, YR Lee, M Won, MJ Chung … - The Journal of Immunology, 2009 - Am Assoc Immnol
TNF receptor 1 can activate signaling pathways leading to the activation of NF-
B. A20, an NF- B-inducible protein, negatively regulates these signaling
pathways and acts as an anti-inflammatory mediator. Therefore, A20 is ...
Cited by 1 - Related articles - All 3 versions


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