DS Luciani, KS Gwiazda, TLB Yang, TB … - Diabetes, 2009 - Am Diabetes Assoc RESULTS—Neither RyR nor IP 3 R inhibition, alone or in combination, caused
robust death within 24 h. In contrast, blocking sarco/endoplasmic reticulum
ATPase (SERCA) pumps depleted ER Ca 2+ and induced marked phosphorylation ... Cited by 3 - Related articles - All 3 versions
CFH Van Schravendijk, R Kiekens, L Heylen, … - Biochemical and biophysical research communications, 1994 - grande.nal.usda.gov Record Detail. Return to previous page, Save: Title: Amino-acid responsiveness in
beta cell subpopulations with different sensitivity to glucose. ... Cited by 2 - Related articles - Cached - BL Direct - All 4 versions
V Fürstova, T Kopska, RFL James, J Kovar - Life sciences, 2008 - Elsevier We tested the effects of various types of fatty acids, differing in the degree
of saturation and in the cis/trans configuration of the double bond, on the
growth and viability of NES2Y cells (a human pancreatic β-cell line). We ... Cited by 2 - Related articles - All 3 versions
- ►endojournals.org K Fujiwara, F Maekawa, K Dezaki, M Nakata, … - Endocrinology, 2007 - Endocrine Soc The effect of long-chain free fatty acids on glucagon secretion from islet
-cells has been a controversial issue. This study examined direct effects of
oleic acid (OA) on glucagon release from rat pancreatic islets and on ... Cited by 2 - Related articles - BL Direct - All 3 versions
DS Luciani, P Ao, X Hu, GL Warnock, JD … - European Journal of Pharmacology, 2007 - Elsevier Glucose-induced insulin release from pancreatic β-cells relies largely on
glucose metabolism and mitochondrial ATP synthesis. Inhibiting the mitochondrial
Na + /Ca 2+ exchanger (mNCE) using 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4 ... Cited by 5 - Related articles
KS Gwiazda, TLB Yang, Y Lin, JD Johnson - American Journal of Physiology- Endocrinology And …, 2009 - Am Physiological Soc There are strong links between obesity, elevated free fatty acids, and type 2
diabetes. Specifically, the saturated fatty acid palmitate has pleiotropic
effects on β-cell function and survival. In the present study, we sought ... Cited by 5 - Related articles - All 3 versions
- ►physiology.org Y Tian, RF Corkey, GC Yaney, PB Goforth, LS … - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc Nonesterified fatty acids such as oleate and palmitate acutely potentiate
insulin secretion from pancreatic islets in a glucose-dependent manner. In
addition, recent studies show that fatty acids elevate intracellular free ... Cited by 3 - Related articles - All 4 versions
ML Peyot, C Guay, MG Latour, J Lamontagne, … - Journal of Biological Chemistry, 2009 - ASBMB Reduced lipolysis in hormone-sensitive lipase-deficient mice is associated with
impaired glucose-stimulated insulin secretion (GSIS), suggesting that endogenous
β-cell lipid stores provide signaling molecules for insulin release. ... Cited by 4 - Related articles - All 4 versions
E Bachar, Y Ariav, M Ketzinel-Gilad, E Cerasi, … - PLoS One, 2009 - pubmedcentral.nih.gov We found that glucose amplifies palmitate-induced ER stress by increasing IRE1α
protein levels and activating the JNK pathway, leading to increased β-cell
apoptosis. Moreover, glucose increased mTORC1 activity and its inhibition ... Cited by 5 - Related articles - All 5 versions
- ►nih.gov KD Jeffrey, EU Alejandro, DS Luciani, TB … - Proceedings of the National Academy of Sciences, 2008 - National Acad Sciences Obesity is a principal risk factor for type 2 diabetes, and elevated fatty acids
reduce β-cell function and survival. An unbiased proteomic screen was used to
identify targets of palmitate in β-cell death. The most significantly ... Cited by 13 - Related articles - BL Direct - All 5 versions
