- ►diabetesjournals.org K Rahmouni, CD Sigmund, WG Haynes, AL … - Diabetes, 2009 - Am Diabetes Assoc RESULTS—Leptin activates ERK1/2 in a receptor-mediated manner that involves
JAK2. Leptin-induced ERK1/2 activation was restricted to the hypothalamic
arcuate nucleus. Pharmacological blockade of hypothalamic ERK1/2 reverses ... Cited by 1 - Related articles - All 3 versions
G Wójcicka, A Jamroz-Wiśniewska, S Widomska, … - Life Sciences, 2008 - Elsevier We investigated if extracellular signal-regulated kinases (ERK) and oxidative
stress are involved in the pathogenesis of arterial hypertension induced by
chronic leptin administration in the rat. Leptin was administered at a dose ... Cited by 6 - Related articles - All 3 versions
GM Leinninger, MG Myers - Acta Physiologica, 2008 - interscience.wiley.com The adipose tissue-derived hormone, leptin, acts via its receptor (LRb) in the
brain to regulate energy balance and neuroendocrine function. In order to
understand leptin action we have explored the physiological function of LRb ... Cited by 8 - Related articles - BL Direct - All 4 versions
E Ueyama, Y Morikawa, T Yasuda, E Senba - Neuroscience letters, 2004 - Elsevier Nutritional status modify the expression of hypothalamic neuropeptides through
various signal molecules, including mitogen-activated protein kinases (MAPKs)
and cAMP/calcium-responsive element-binding protein (CREB), for the ... Cited by 9 - Related articles - All 3 versions
- ►endojournals.org ML Piper, EK Unger, MG Myers Jr, AW Xu - Molecular Endocrinology, 2008 - Endocrine Soc Leptin is a fat-derived hormone that exerts pleiotropic effects on energy
balance and neuroendocrine functions. Mice defective in leptin or its receptor
[leptin receptor, isoform b (LepRb)] exhibit profound obesity, infertility, ... Cited by 9 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org S Chua - Diabetes, 2009 - Am Diabetes Assoc Leptin is a critical regulator of energy balance in mammals and has served as a
launch point for innumerable studies examining the regulation of food intake and
energy expenditure (1). At high physiological concentrations, leptin causes ... Related articles - All 4 versions
K Rahmouni - Current Diabetes Reports, 2003 - Springer Introduction The importance of the central nervous system in the regula- tion of
energy homeostasis was derived from the clinical observation of excessive
subcutaneous fat in patients with pituitary tumors. The role of the ... Related articles - BL Direct - All 2 versions
RL Leshan, M Björnholm, H Münzberg, MG … - Obesity, 2006 - nature.com The increasing incidence of obesity in developed nations represents an
ever-growing challenge to health care by promoting diabetes and other diseases.
The discovery of the hormone, leptin, a decade ago has facilitated the ... Cited by 24 - Related articles - All 4 versions
EC Villanueva, H Munzberg, D Cota, RL … - Endocrinology, 2009 - Endocrine Soc The medial basal hypothalamus, including the arcuate nucleus (ARC) and the
ventromedial hypothalamic nucleus (VMH), integrates signals of energy status to
modulate metabolism and energy balance. Leptin and feeding regulate the ... Related articles - All 3 versions
EC Villanueva, MG Myers - International Journal of Obesity, 2008 - nature.com The adipocyte-derived hormone, leptin, signals the status of body energy stores
to the central nervous system to regulate appetite and energy expenditure. A
specific long-form leptin receptor (LepRb), a type I cytokine receptor, ... Cited by 1 - Related articles - All 3 versions
