- ►diabetesjournals.org AL Putnam, TM Brusko, MR Lee, W Liu, GL … - Diabetes, 2009 - Am Diabetes Assoc RESULTS—Both CD4 + CD127 lo/− and CD4 + CD127 lo/− CD25 + T-cells could be
expanded and used as Tregs. However, expansion of CD4 + CD127 lo/− cells
required the addition of rapamycin to maintain lineage purity. In contrast, ... Cited by 10 - Related articles - All 4 versions
- Free from Publisher F Flores-Borja, EC Jury, C Mauri, MR … - Proceedings of the National Academy of Sciences, 2008 - nihongo.j-talk.com The ultimate goal for the treatment of autoimmunity is to restore immunological
tolerance. Regulatory T cells (Treg) play a central role in immune tolerance,
and Treg functional abnormalities have been identified in different ... Cited by 9 - Related articles - All 9 versions
EM Schmidt, CJ Wang, GA Ryan, LE Clough, … - The Journal of Immunology, 2009 - Am Assoc Immnol The CTLA-4 pathway is recognized as a major immune inhibitory axis and is a key
therapeutic target for augmenting antitumor immunity or curbing autoimmunity.
CTLA-4-deficient mice provide the archetypal example of dysregulated immune ... Cited by 8 - Related articles - All 2 versions
D Golshayan, JC Wyss, CW Abulker, SC … - International Immunopharmacology, 2009 - Elsevier The mechanisms by which CD4 + CD25 + Foxp3 + T (Treg) cells regulate effector T
cells in a transplantation setting and their in vivo homeostasis still remain to
be clarified. Using a mouse adoptive transfer model, we analyzed the in ... Cited by 2 - Related articles - All 2 versions
[CITATION] Acute rejection is associated with high FOXP3 mRNA expression levels in the graft, but not in …
IE Dijke, K Caliskan, SS Korevaar, AH Balk, … - J Heart Lung Transplant, 2007 Cited by 2 - Related articles
C Nazarov-Stoica, J Surls, C Bona, S … - The Journal of Immunology, 2009 - Am Assoc Immnol Naturally occurring CD4 + 25 high Foxp3 + T regulatory (T-reg) cells are
critical for maintaining tolerance to self and non-self Ags. The Foxp3
master-regulatory gene and CD28 costimulation are both required for thymic ... Cited by 2 - Related articles - All 3 versions
[CITATION] Conversion to steroid free rapamycin, reduce percentages of CD4+ CD25highFoxP3+ T cells …
M Zeng, E Guinet, M Nouri-Shirazi - Transplant Immunology, 2009 - Elsevier Targeting the CD28/B7 interaction remains among the most promising approaches to
treat transplant rejection. A drawback to this approach is however the
observations of decreased numbers of naturally occurring regulatory T cells ... Cited by 3 - Related articles - All 2 versions
R Wang, Q Wan, L Kozhaya, H Fujii, D … - PLoS One, 2008 - pubmedcentral.nih.gov Regulatory T (T reg ) cells control immune activation and maintain tolerance.
How T regs mediate their suppressive function is unclear. Here we identified a
cell surface molecule, called GARP, (or LRRC32), which within T cells is ... Cited by 11 - Related articles - All 7 versions
- ►jimmunol.org AA Hombach, D Kofler, A Hombach, G Rappl, … - The Journal of Immunology, 2007 - Am Assoc Immnol The strength of immune repression by regulatory T (Treg) cells is thought to
depend on the efficiency of Treg cell activation. The stimuli and their
individual strength required to activate resting human Treg cells, however, ... Cited by 12 - Related articles - All 3 versions
