- ►diabetesjournals.org G da Silva Xavier, MK Loder, A McDonald, AI … - Diabetes, 2009 - Am Diabetes Assoc OBJECTIVE Polymorphisms in the human TCF7L2 gene are associated with reduced
insulin secretion and an increased risk of type 2 diabetes. However, the
mechanisms by which TCF7L2 affect insulin secretion are still unclear. We ... Cited by 9 - Related articles - All 3 versions
- ►diabetesjournals.org AL Gloyn, M Braun, P Rorsman - Diabetes, 2009 - Am Diabetes Assoc Type 2 diabetes is associated with impaired insulin secretion. Both 1st- and
2nd-phase insulin secretion are reduced, but the effect is particularly
pronounced for the 1st phase. The processes culminating in impaired insulin ... Cited by 2 - Related articles - All 3 versions
P Butler - Novartis Foundation symposium, 2000 - ncbi.nlm.nih.gov Insulin is secreted in a pulsatile manner. Recently it has been shown that
almost all (approximately 70-100%) of insulin is secreted in discrete insulin
secretory bursts occurring approximately every 6 min. Furthermore, it has ... Cited by 5 - Related articles - BL Direct - All 3 versions
- ►jhc.org D Tornehave, P Kristensen, J Romer, LB … - Journal of Histochemistry and Cytochemistry, 2008 - Histochemical Soc GLP-1 acts through a G protein–coupled receptor (GLP-1R) (Thorens 1992 Go ),
which is expressed in several tissues including the pancreatic islets (Bullock
et al. 1996 Go ). Using radioligand binding assays, GLP-1Rs have been ... Cited by 5 - Related articles - All 5 versions
K Pilgaard, CB Jensen, JH Schou, V Lyssenko, … - Diabetologia, 2009 - Springer Abstract Aims/hypothesis We studied the physiological, metabolic and hormonal
mechanisms underlying the elevated risk of type 2 diabetes in carriers of TCF7L2
gene. Methods We undertook genotyping of 81 healthy young Danish men for ... Cited by 6 - Related articles - All 2 versions
I Processing - Am Diabetes Assoc Insulin Processing. Islets were incubated overnight in RPMI 1640 with 11.1 mM
glucose plus 10% fetal bovine serum (FBS) and washed twice in Cys/Met-free
Dulbecco's Modified Eagle Medium (DMEM) containing 25.5mM glucose. The ... Related articles
ER Pearson - Diabetologia, 2009 - Springer We are living through a revolution in genetics research. At present, barely a
week goes by without a flurry of reports revealing robustly replicated loci
associating with a common complex disease. Diabetes was one of the first ... Related articles - All 2 versions
L Groop, V Lyssenko - Diabetes, Obesity and Metabolism, 2009 - interscience.wiley.com Although the genetic causes of monogenic disorders have been successfully
identified in the past, the success in dissecting the genetics of complex
polygenic diseases has until now been limited. With the introduction of ... Related articles - All 3 versions
