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Scholar Results 1 - 10 of about 101 related to Sutherland: Interleukin-21 Is Required for the Development of Type 1 Diabetes in NOD Mice. (0.11 sec) 

Interleukin-21 Is Required for the Development of Type 1 Diabetes in NOD Mice

- diabetesjournals.org
APR Sutherland, T Van Belle, AL Wurster, A … - Diabetes, 2009 - Am Diabetes Assoc
4 Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital
and Department of Medicine, Harvard Medical School, Boston, Massachusetts. ...
Corresponding author: Matthias von Herrath, matthias{at}liai.org, and ...
Cited by 4 - Related articles - All 3 versions

A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus …


JA Bubier, TJ Sproule, O Foreman, R Spolski … - Proceedings of the National Academy of Sciences, 2009 - National Acad Sciences
Interleukin 21 (IL-21) is a pleiotropic cytokine produced by CD4 T cells that
affects the differentiation and function of T, B, and NK cells by binding to a
receptor consisting of the common cytokine receptor γ chain and the IL-21 ...
Cited by 7 - Related articles - All 8 versions

A Common Exonic Variant of Interleukin21 Confers Susceptibility to Atopic Asthma


R Chatterjee, J Batra, B Ghosh - Int Arch Allergy Immunol, 2009 - content.karger.com
Background: Interleukin (IL)-21, an IL-2 family multifunctional cytokine, is
produced by activated CD4+ T cells and is known to potentially affect growth,
survival and function of numerous immune cells. As IL-21 regulates IgE ...
Cited by 2 - Related articles - All 5 versions

Rheumatologic and autoimmune manifestations of primary immunodeficiency disorders


R Goyal, AC Bulua, NP Nikolov, PL … - Current Opinion in Rheumatology, 2009 - journals.lww.com
Purpose of review: Although it may seem paradoxical, primary immunodeficiency
disorders are frequently complicated by autoimmune and inflammatory conditions.
These conditions pose significant diagnostic and therapeutic challenges for ...
Cited by 2 - Related articles - All 7 versions

Melan-A–specific Cytotoxic T Cells Are Associated with Tumor Regression and …


O Klein, LM Ebert, T Nicholaou, J Browning, … - Clinical Cancer Research, 2009 - AACR
Purpose: Ipilimumab is a monoclonal antibody that blocks the immune-inhibitory
interaction between CTL antigen 4 (CTLA-4) and its ligands on T cells. Clinical
trials in cancer patients with ipilimumab have shown promising antitumor ...
Cited by 2 - Related articles - All 3 versions

Cutting edge: in vitro generated Th17 cells maintain their cytokine expression program in …


R Nurieva, XO Yang, Y Chung, C Dong - The Journal of Immunology, 2009 - Am Assoc Immnol
Upon activation, naive CD4 + T cells differentiate into effector Th cell
subsets. The stability and plasticity of effector Th cells have not been well
understood. In this study we used an IL-17F-red fluorescent protein ...
Cited by 3 - Related articles - All 2 versions

Breakdown of T cell tolerance and autoimmunity in primary immunodeficiency—lessons …


LS Westerberg, C Klein, SB Snapper - Current Opinion in Immunology, 2008 - Elsevier
A key feature of the immune system is the capacity to monitor and control
infections from non-self pathogens while maintaining tolerance to self-antigens.
Primary immunodeficiencies (PID) are characterized by an increased ...
Cited by 3 - Related articles - All 3 versions

IL-21 signaling is critical for the development of type I diabetes in the NOD mouse


R Spolski, M Kashyap, C Robinson, Z Yu, WJ … - Proceedings of the National Academy of Sciences, 2008 - National Acad Sciences
IL-21 is a pleiotropic type I cytokine that shares the common cytokine receptor
γ chain and plays important roles for normal Ig production, terminal B cell
differentiation to plasma cells, and Th17 differentiation. IL-21 is ...
Cited by 18 - Related articles - All 8 versions

IL-21: an executor of B cell fate


D Konforte, N Simard, CJ Paige - The Journal of Immunology, 2009 - Am Assoc Immnol
IL-21 is a type I cytokine that shares the common receptor -chain with IL-2,
IL-4, IL-7, IL-9, and IL-15. B cells are one of the lymphoid cell types whose
development and function are regulated by IL-21. Depending on the interplay ...
Cited by 5 - Related articles - All 3 versions

IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans …


H Jin, MK Oyoshi, Y Le, T Bianchi, S Koduru, … - The Journal of Clinical Investigation, 2009 - pubmedcentral.nih.gov
Atopic dermatitis (AD) is a common allergic inflammatory skin disease caused by
a combination of intense pruritus, scratching, and epicutaneous (ec)
sensitization with allergens. To explore the roles of IL-21 and IL-21 ...
Cited by 4 - Related articles - All 9 versions


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