- ►diabetesjournals.org FS Wong, K Siew… - Diabetes, 2009 - Am Diabetes Assoc OBJECTIVE We have previously reported a highly diabetogenic CD8 T-cell clone,
G9C8, in the nonobese diabetic (NOD) mouse, specific to low-avidity insulin
peptide B15-23, and cells responsive to this antigen are among the earliest ... Cited by 1 - Related articles - All 3 versions
- ►nih.gov [PDF] C McBeth, A Seamons, JC Pizarro, SJ … - Journal of molecular biology, 2008 - Elsevier We report crystal structures of a negatively selected T cell receptor (TCR) that
recognizes two IA u -restricted myelin basic protein peptides and one of its
peptide/major histocompatibility complex (pMHC) ligands. Unusual ... Cited by 5 - Related articles - All 4 versions
L Steinman - Journal of the Neurological Sciences, 2008 - Elsevier By studying gene transcripts in active lesions of multiple sclerosis via robotic
sequencing and gene chips, as well as studying the very same tissue via
proteomics, we have discovered several targets at the tipping points in ... Cited by 4 - Related articles - All 17 versions
E Palmer, D Naeher - Nature Reviews Immunology, 2009 - nature.com The affinity of the T-cell receptor (TCR) for self antigen is the basis for the
selection of a useful (MHC-restricted) and safe (self-tolerant) T-cell
repertoire. However, it has been difficult to understand how thymocytes ... Cited by 4 - Related articles - All 3 versions
C Baker, LG Petrich de Marquesini, AJ … - Journal of Clinical Immunology, 2008 - Springer Abstract Purpose In this study, we explored the breadth of CD8 T cell reactivity
to preproinsulin (PPI) in type 1 diabetes. Materials and Methods We tested a
complete peptide set in pools covering all 406 potential 8–11mer epitopes ... Cited by 6 - Related articles - All 2 versions
Z Hovhannisyan, A Weiss, A Martin, M Wiesner, … - Nature, 2008 - nature.com Major histocompatibility complex (MHC) class II alleles HLA-DQ8 and the mouse
homologue IA g7 lacking a canonical aspartic acid residue at position 57 are
associated with coeliac disease 1, 2 and type I diabetes 3, 4 . However, ... Cited by 5 - Related articles - All 4 versions
P Narendran, AM Neale, BH Lee, K Ngui, RJ … - Proceedings of the National Academy of Sciences, 2006 - National Acad Sciences Genes for peripheral tissue-restricted self-antigens are expressed in thymic and
hematopoietic cells. In thymic medullary epithelial cells, self-antigen
expression imposes selection on developing autoreactive T cells and ... Cited by 7 - Related articles - BL Direct - All 9 versions
- ►ox.ac.uk [PDF] M Harkiolaki, SL Holmes, P Svendsen, JW … - Immunity, 2009 - Elsevier Environmental factors account for 75% of the risk of developing multiple
sclerosis (MS). Numerous infections have been suspected as environmental disease
triggers, but none of them has consistently been incriminated, and it is ... Cited by 7 - Related articles - All 6 versions
S Ferri, L Muratori, M Lenzi, A Granito, FB … - Current pharmaceutical design, 2008 - ingentaconnect.com Abstract: Hepatitis C virus (HCV) infection is characterized by a number of
autoreactive manifestations, such as autoantibody produc- tion, cryoglobulinemia
and thyroid disorders. We will analyse critically the mechanisms invoked, ... Cited by 6 - Related articles - All 3 versions
- ►rupress.org JK Archbold, WA Macdonald, S Gras, LK Ely, … - Journal of Experimental Medicine, 2009 - jem.rupress.org Human leukocyte antigen (HLA) gene polymorphism plays a critical role in
protective immunity, disease susceptibility, autoimmunity, and drug
hypersensitivity, yet the basis of how HLA polymorphism influences T cell ... Cited by 7 - Related articles - All 7 versions
