- ►diabetesjournals.org F Moore, ML Colli, M Cnop, MI Esteve, AK … - Diabetes, 2009 - Am Diabetes Assoc OBJECTIVE The pathogenesis of type 1 diabetes has a strong genetic component.
Genome-wide association scans recently identified novel susceptibility genes
including the phosphatases PTPN22 and PTPN2. We hypothesized that PTPN2 ... Cited by 1 - Related articles - All 3 versions
- ►diabetesjournals.org AP Martin, S Rankin, S Pitchford, IF Charo, GC … - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—We tested the hypothesis that macrophage
accumulation into the islets is caused by overexpression of the chemokine CCL2.
To test this hypothesis, we generated transgenic mice and evaluated the ... Cited by 5 - Related articles - All 3 versions
P Concannon, SS Rich, GT Nepom - New England Journal of Medicine, 2009 - content.nejm.org In 1976, the noted human geneticist James Neel titled a book chapter "Diabetes
Mellitus: A Geneticist's Nightmare." 1 Over the past 30 years, however, the
phenotypic and genetic heterogeneity of diabetes has been painstakingly ... Cited by 6 - Related articles - All 2 versions
EN Gurzov, F Ortis, L Bakiri, EF Wagner, DL … - PLoS One, 2008 - pubmedcentral.nih.gov Cytokines contribute to pancreatic β-cell apoptosis in type 1 diabetes (T1D) by
modulation of β-cell gene expression networks. The transcription factor
Activator Protein-1 (AP-1) is a key regulator of inflammation and ... Cited by 7 - Related articles - All 7 versions
DL Eizirik, ML Colli, F Ortis - Nature Reviews Endocrinology, 2009 - phx1.medscape.com Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease with a strong
inflammatory component. The latest studies indicate that innate immunity and
inflammatory mediators have a much broader role in T1DM than initially ... Cited by 7 - Related articles - All 8 versions
- ►diabetesjournals.org [PDF] Z Dogusan, M García, D Flamez, L … - Diabetes, 2008 - Am Diabetes Assoc 1 Laboratory of Experimental Medicine, Université Libre de Bruxelles, Brussels,
Belgium. 2 Centre d'Immunologie de Marseille-Luminy, CNRS-INSERM- Université de
la Mediterranée, Marseille, France. 3 Institute of Medical Immunology, ... Cited by 8 - Related articles - All 2 versions
NE Magnusson, AK Cardozo, M Kruhøffer, DL … - BMC bioinformatics, 2005 - biomedcentral.com Type 1 diabetes mellitus (T1DM) is a autoimmune disease caused by a long-term
negative balance between immune-mediated beta-cell damage and beta-cell
repair/regeneration. Following immune-mediated damage the beta-cell fate ... Cited by 8 - Related articles - Cached - All 8 versions
CM Filippi, MG von Herrath - Diabetes, 2008 - Am Diabetes Assoc The most popular hypothesis circulating within and beyond the scientific
community is that viral infections enhance or elicit autoimmune disorders such
as type 1 diabetes. Indeed, viruses can injure β-cells and have been ... Cited by 8 - Related articles - All 8 versions
J De Miranda, K Yaddanapudi, M Hornig, WI … - The FASEB Journal, 2009 - FASEB RNA virus replication results in expression of double-stranded RNA (ds-RNA)
molecules that trigger innate immune responses through interactions with both
intracellular and extracellular receptors. We investigated the ... Cited by 1 - Related articles - All 4 versions
J Lempainen, O Vaarala, M Mäkelä, R Veijola … - Journal of Autoimmunity, 2009 - Elsevier Genetic heterogeneity may affect the analysis of risk factors associated with
type 1 diabetes (T1D). We studied the effect of the INS −23A/T, PTPN22
1858C/T, and CTLA-4 +49A/G polymorphisms on the emergence of T1D-associated ... Cited by 1 - Related articles - All 3 versions
