- ►diabetesjournals.org S Hamada, K Hara, T Hamada, H Yasuda, H … - Diabetes, 2009 - Am Diabetes Assoc OBJECTIVE Components of insulin/IGF-1 receptor–mediated signaling pathways in
pancreatic β-cells have been implicated in the development of diabetes, in part
through the regulation of β-cell mass in vivo. Studies in vitro have shown ... Cited by 1 - Related articles - All 2 versions
- ►cell.com H Mori, K Inoki, H Münzberg, D Opland, M … - Cell Metabolism, 2009 - Elsevier The mammalian target of rapamycin (mTOR) promotes anabolic cellular processes in
response to growth factors and metabolic cues. The TSC1 and TSC2 tumor
suppressors are major upstream inhibitory regulators of mTOR signaling. ... Cited by 4 - Related articles - All 4 versions
N Balcazar, A Sathyamurthy, L Elghazi, A … - Journal of Biological Chemistry, 2009 - ASBMB Growth factors, insulin signaling, and nutrients are important regulators of
β-cell mass and function. The events linking these signals to the regulation of
β-cell mass are not completely understood. The mTOR pathway integrates ... Cited by 5 - Related articles - All 3 versions
- ►nih.gov Y Shigeyama, T Kobayashi, Y Kido, N … - Molecular and Cellular Biology, 2008 - Am Soc Microbiol Recent studies have demonstrated the importance of insulin or insulin-like
growth factor 1 (IGF-1) for regulation of pancreatic β-cell mass. Given the
role of tuberous sclerosis complex 2 (TSC2) as an upstream molecule of mTOR ... Cited by 9 - Related articles - BL Direct - All 7 versions
E Zahr, RD Molano, A Pileggi, H Ichii, S San … - Transplantation Proceedings, 2008 - Elsevier During pregnancy a high rate of β-cell proliferation occurs, making of this a
useful model for the study of islet cell expansion in vivo. We used the murine
pregnancy model to assess the effect of Rapamycin treatment on islet cell ... Cited by 3 - Related articles - All 5 versions
D Gupta, TL Jetton, RM Mortensen, SZ Duan, … - Journal of Biological Chemistry, 2008 - ASBMB We reported that peroxisome proliferator-activated receptor γ (PPARγ)
transcriptionally regulates the β-cell differentiation factor pancreatic
duodenal homeobox (PDX)-1 based on in vitro RNA interference studies. We ... Cited by 3 - Related articles - All 3 versions
- ►diabetesjournals.org H Liu, MS Remedi, KL Pappan, G Kwon, N … - Diabetes, 2009 - Am Diabetes Assoc OBJECTIVE—Our previous studies demonstrated that nutrient regulation of
mammalian target of rapamycin (mTOR) signaling promotes regenerative processes
in rodent islets but rarely in human islets. Our objective was to extend ... Cited by 1 - Related articles - All 3 versions
H Mori, K Inoki, D Opland, H Munzberg, EC … - American Journal of Physiology- Endocrinology And …, 2009 - Am Physiological Soc TSC1 is a tumor suppressor that associates with TSC2 to inactivate Rheb, thereby
inhibiting signaling by the mammalian target of rapamycin (mTOR) complex 1
(mTORC1). mTORC1 stimulates cell growth by promoting anabolic cellular ... Related articles - All 3 versions
- ►pnas.org L Rachdi, N Balcazar, F Osorio-Duque, L … - Proceedings of the National Academy of Sciences, 2008 - National Acad Sciences Regulation of pancreatic β cell mass and function is a major determinant for
the development of diabetes. Growth factors and nutrients are important
regulators of β cell mass and function. The signaling pathways by which ... Cited by 10 - Related articles - All 6 versions
G Kwon, CA Marshall, H Liu, KL Pappan, MS … - Journal of Biological Chemistry, 2006 - ASBMB The aim of this study was to define metabolic signaling pathways that mediate
DNA synthesis and cell cycle progression in adult rodent islets to devise
strategies to enhance survival, growth, and proliferation. Since previous ... Cited by 18 - Related articles - BL Direct - All 6 versions
