- ►diabetesjournals.org MM Rankin, JA Kushner - Diabetes, 2009 - Am Diabetes Assoc OBJECTIVE Regeneration of the insulin-secreting β-cells is a fundamental
research goal that could benefit patients with either type 1 or type 2 diabetes.
β-Cell proliferation can be acutely stimulated by a variety of stimuli in ... Cited by 6 - Related articles - All 3 versions
- ►diabetesjournals.org SI Tschen, S Dhawan, T Gurlo, A Bhushan - Diabetes, 2009 - Am Diabetes Assoc 2 Molecular Biology Institute, University of California, Los Angeles, Los
Angeles, California. ... Corresponding author: Anil Bhushan,
abhushan{at}mednet.ucla.edu. ... OBJECTIVE The aim of this study was to ... Cited by 6 - Related articles - All 3 versions
E Manesso, GM Toffolo, Y Saisho, AE Butler, … - American Journal of Physiology- Endocrinology And …, 2009 - Am Physiological Soc Type 2 diabetes is characterized by hyperglycemia, a deficit in β-cells,
increased β-cell apoptosis, and islet amyloid derived from islet amyloid
polypeptide (IAPP). These characteristics are recapitulated in the human ... Related articles - All 3 versions
CW Liew, A Holman, RN Kulkarni - Diabetes, Obesity and Metabolism, 2009 - interscience.wiley.com Telomerase is a specialized reverse transcriptase that is responsible for
extending and preserving the end of the chromosomes (telomeres). Telomerase
plays a key role in regulating the lifespan of mammalian cells and is ... Related articles
M Cnop, SJ Hughes, M Igoillo-Esteve, MB … - Diabetologia - Springer Abstract Aims/hypothesis Defects in pancreatic beta cell turnover are implicated
in the pathogenesis of type 2 diabetes by genetic markers for diabetes.
Decreased beta cell neogenesis could contribute to diabetes. The longevity ... Related articles - All 2 versions
WF Graier, R Malli, GM Kostner - Trends in Endocrinology & Metabolism, 2009 - Elsevier Lipotoxicity occurs as a consequence of chronic exposure of non-adipose tissue
and cells to elevated concentrations of fatty acids, triglycerides and/or
cholesterol. The contribution of mitochondria to lipotoxic cell ... Cited by 1 - Related articles - All 3 versions
A Granger, JA Kushner - Journal of Internal Medicine, 2009 - interscience.wiley.com It is also possible that your web browser is not configured or not able to
display style sheets. In this case, although the visual presentation will be
degraded, the site should continue to be functional. We recommend using the ... Cited by 1 - Related articles - All 3 versions
G Fontés, M Semache, DK Hagman, C Tremblay … - Diabetes, 2009 - ncbi.nlm.nih.gov Objective: Prolonged exposure of pancreatic beta cells to simultaneously
elevated levels of fatty acids and glucose (glucolipotoxicity) impairs insulin
gene transcription. However, the intracellular signalling pathways ... Cited by 1 - Related articles - All 3 versions
Y Saisho, E Manesso, T Gurlo, C Huang, GM … - American Journal of Physiology- Endocrinology And …, 2009 - Am Physiological Soc An obstacle to development of methods to quantify β-cell turnover from pancreas
tissue is the lack of conversion factors for the frequency of β-cell
replication or apoptosis detected by immunohistochemistry to rates of ... Cited by 1 - Related articles - All 3 versions
SG Scott - The Journal of Pathology and Bacteriology - interscience.wiley.com It is also possible that your web browser is not configured or not able to
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