K Brands, E Colvin, LJ Williams, R Wang, RB Lock, BE … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—The use of human fetal pancreatic tissue may provide a potential source of transplantable
β-cells as a therapy for type 1 diabetes. Human fetal pancreas has a remarkable capacity to grow
and differentiate in vivo and has been shown to reverse diabetes in rodents. However, it ... Cited by 7 - Related articles - BL Direct - All 4 versions
M KING, T Pearson, LD Shultz, J Leif, R … - ANNALS-NEW …, 2007 - interscience.wiley.com Abstract : The use of "humanized" mice represents an appealing translational model for studies
of the pathogenesis of immune-mediated diseases and for the evaluation of potential
therapeutics. The utility of humanized mice depends on their ability to model the human ... Cited by 5 - Related articles - BL Direct - All 8 versions
G Fousteri, M von Herrath - Diabetes, 2008 - Am Diabetes Assoc Type 1 diabetes results from immune-mediated destruction of insulin-producing β-cells of the
pancreas. The disease manifests itself symptomatically when the resident β-cells become unable
to maintain normoglycemia. In human insulitis, mainly CD8 lymphocytes and B-cells, but ... Related articles - BL Direct - All 3 versions
G Fousteri, M von Herrath - DIABETES, 2008 - Am Diabetes Assoc T ype 1 diabetes results from immune-mediated destruction of insulin-producing -cells of the
pancreas. The disease manifests itself symptom- atically when the resident -cells become unable
to maintain normoglycemia. In human insulitis, mainly CD8 lymphocytes and B-cells, but ... Related articles
BE Tuch, K Kannangara - Drug Discovery Today: Therapeutic Strategies, 2009 - Elsevier Replacing the 350 million β cells destroyed in people with type 1 diabetes has traditionally been
sought by transplanting human pancreatic tissue obtained after death. Alternative sources of
exogenous surrogate β cells being examined include stem cells, fetal pancreas and cells ... Related articles
MF Lopes, AMS Cabrita, JAB Patrício - Pediatric surgery international, 2000 - Springer Abstract Adult intestinal allografts have demonstrated high immunogenicity in human
transplantation, making the search for new and more favorable grafts an actual problem. Accepting
that fetal and newborn immune systems are relatively immature, their intestines could be ... Cited by 8 - Related articles - BL Direct - All 3 versions
Z Si, BE Tuch, DA Walsh - Cells Tissues Organs, 2000 - content.karger.com Only a small component of human fetal pancreas consists of cells, and yet this tissue is capable
of normalizing the blood glucose levels of diabetic recipients when transplanted. The time taken
to achieve this goal is several months, during which time the tissue proliferates and ... Cited by 9 - Related articles - BL Direct - All 4 versions
LD Shultz, T Pearson, M KING, L GIASSI, … - ANNALS-NEW …, 2007 - interscience.wiley.com Abstract : There are many rodent models of autoimmune diabetes that have been used to study
the pathogenesis of human type 1 diabetes (T1D), including the non-obese diabetic (NOD)
mouse, the biobreeding (BB) rat, and the transgenic mouse models. However, mice and ... Cited by 9 - Related articles - BL Direct - All 7 versions
M Cananzi, A Atala, P De Coppi - Reproductive BioMedicine Online, 2009 - ingentaconnect.com Paolo De Coppi is a Clinical Senior Lecturer and Consultant in Paediatric Surgery at the UCL
Institute of Child Health and Great Ormond Street Hospital, London, UK. His clinical training and
PhD in tissue engineering and cell transplantation (2002) were undertaken at the ... Cited by 2 - Related articles - All 2 versions
- ►diabetesjournals.org N Fiaschi-Taesch, TA Bigatel, B Sicari, KK Takane, F … - Diabetes, 2009 - Am Diabetes Assoc OBJECTIVES To comprehensively inventory the proteins that control the G1/S cell cycle checkpoint
in the human islet and compare them with those in the murine islet, to determine whether these
might therapeutically enhance human β-cell replication, to determine whether human ... Cited by 1 - Related articles - All 3 versions
