- ►diabetesjournals.org MC Akerfeldt, J Howes, JY Chan, VA Stevens, N … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Cytokines and palmitate triggered ER stress in β-cells as evidenced by increased
phosphorylation of PKR-like ER kinase (PERK), eukaryotic initiation factor (EIF)2α, and Jun NH
2 -terminal kinase (JNK) and increased expression of activating transcription factor ... Cited by 9 - Related articles - All 3 versions
- ►biologists.org DA Cunha, P Hekerman, L Ladriere, A Bazarra- … - Journal of cell …, 2008 - jcs.biologists.org Free fatty acids (FFA) cause apoptosis of pancreatic β-cells and might contribute to β-cell loss
in type 2 diabetes via the induction of endoplasmic reticulum (ER) stress. We studied here the
molecular mechanisms implicated in FFA-induced ER stress initiation and apoptosis in ... Cited by 23 - Related articles - All 5 versions
Y Ariyama, Y Tanaka, H Shimizu, K Shimomura, S … - Metabolism, 2008 - Elsevier Low expression of antioxidant enzymes makes pancreatic β-cells susceptible to cell damage
by oxidative stress. Pancreatic β-cell loss caused by endoplasmic reticulum stress is associated
with the onset of diabetes mellitus. The present studies were undertaken to investigate a ... Cited by 2 - Related articles - All 10 versions
D Eizirik, F Moore, D Flamez, F Ortis - Biochemical Society …, 2008 - biochemsoctrans.org Accumulating evidence indicates that β-cells die by apoptosis in T1DM (Type 1 diabetes
mellitus). Apoptosis is an active gene-directed process, and recent observations suggest that
β-cell apoptosis depends on the parallel and/or sequential up- and down-regulation of ... Cited by 9 - Related articles - Cached - BL Direct - All 6 versions
KT Chambers, JA Unverferth, SM Weber, RC Wek, F … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—UPR activation correlates with β-cell death in interleukin (IL)-1–treated rat islets.
NO mediates both cytokine-induced UPR activation and β-cell death as NO synthase inhibitors
attenuate each of these IL-1–stimulated events. Importantly, cytokines and tunicamycin, a ... Cited by 10 - Related articles - BL Direct - All 7 versions
- ►endojournals.org D Mokhtari, JW Myers, N Welsh - Endocrinology, 2008 - Endocrine Soc The aim of the present investigation was to characterize the role of the MAPK kinase kinase-1
(MEKK-1) in stress-induced cell death of insulin producing cells. We observed that transient overexpression
of the wild type MEKK-1 protein in the insulin-producing cell lines RIN-5AH and βTC-6 ... Cited by 4 - Related articles - BL Direct - All 3 versions
- ►endojournals.org M Boni-Schnetzler, J Thorne, G Parnaud, L … - Journal of Clinical …, 2008 - Endocrine Soc Results: Gene array analysis of RNA from β-cells of individuals with T2DM revealed increased
expression of IL-1β mRNA. Real-time PCR confirmed increased IL-1β expression in six of 10
T2DM samples, with minimal or no expression in nine control samples. In cultured human ... Cited by 8 - Related articles - All 4 versions
B Song, D Scheuner, D Ron, S Pennathur, … - The Journal of …, 2008 - pubmedcentral.nih.gov The progression from insulin resistance to type 2 diabetes is caused by the failure of pancreatic
β cells to produce sufficient levels of insulin to meet the metabolic demand. Recent studies indicate
that nutrient fluctuations and insulin resistance increase proinsulin synthesis in β cells ... Cited by 23 - Related articles - All 7 versions
- ►diabetesjournals.org P Pirot, F Ortis, M Cnop, Y Ma, LM Hendershot, DL … - Diabetes, 2007 - Am Diabetes Assoc Endoplasmic reticulum stress–mediated apoptosis may play an important role in the destruction
of pancreatic β-cells, thus contributing to the development of type 1 and type 2 diabetes. One
of the regulators of endoplasmic reticulum stress–mediated cell death is the CCAAT/ ... Cited by 23 - Related articles - BL Direct - All 8 versions
EN Gurzov, F Ortis, L Bakiri, EF Wagner, DL Eizirik - PLoS One, 2008 - pubmedcentral.nih.gov Cytokines contribute to pancreatic β-cell apoptosis in type 1 diabetes (T1D) by modulation of
β-cell gene expression networks. The transcription factor Activator Protein-1 (AP-1) is a key regulator
of inflammation and apoptosis. We presently evaluated the function of the AP-1 subunit ... Cited by 8 - Related articles - All 7 versions
