- ►nih.gov Y Jiang, W Nishimura, D Devor-Henneman, D … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Selective deletion of survivin in pancreatic endocrine cells in the
mouse had no discernible effects during embryogenesis but was associated with
striking decreases in β-cell number after birth, leading to hyperglycemia ... Cited by 4 - Related articles - All 5 versions
M Gannon, E Tweedie Ables, L Crawford, D … - Developmental biology, 2008 - Elsevier The pdx1 gene is essential for pancreatic organogenesis in humans and mice; pdx1
mutations have been identified in human diabetic patients. Specific inactivation
of pdx1 in adult β cells revealed that this gene is required for ... Cited by 10 - Related articles - All 4 versions
M Kapasa, I Serafimidis, A Gavalas, S … - Genomics, 2008 - Elsevier WISP1 and CTGF are members of the CCN family of growth factors encoding
extracellular matrix proteins participating in several developmental and
tumorigenic processes. Both are induced by the WNT signaling pathway, and ... Cited by 1 - Related articles - All 3 versions
A Radziszewska, SA Schroer, D Choi, P … - Journal of Biological Chemistry, 2009 - ASBMB Progressive β-cell insufficiency is a hallmark of both type 1 and 2 diabetes.
Although the instigating factors that lead to β-cell failure in these two types
of diabetes may differ, the apoptotic machinery that results in β-cell ... Cited by 1 - Related articles - All 3 versions
LW Crawford, ET Ables, YA Oh, B Boone, S … - PLoS One, 2008 - pubmedcentral.nih.gov In the past decade, several transcription factors critical for pancreas
organogenesis have been identified. Despite this success, many of the factors
necessary for proper islet morphogenesis and function remain ... Cited by 2 - Related articles - All 5 versions
- ►diabetesjournals.org A Fukuda, Y Kawaguchi, K Furuyama, S … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—Most pancreatic endocrine cells derive from Ptf1a-expressing
progenitor cells. In humans, nonsense mutations in Ptf1a have recently been
identified as a cause of permanent neonatal diabetes associated with ... Cited by 2 - Related articles - All 4 versions
LA Crawford, MA Guney, YA Oh, RA DeYoung, … - Molecular Endocrinology, 2009 - Endocrine Soc The factors necessary for normal pancreatic islet morphogenesis have not been
well characterized. Here we report that connective tissue growth factor (CTGF)
is involved in the establishment of normal islet endocrine cell ratio and ... Cited by 2 - Related articles - All 3 versions
- ►shouxi.net E Tweedie, I Artner, L Crawford, G … - Diabetes, 2006 - Am Diabetes Assoc The Onecut homeodomain transcription factor hepatic nuclear factor 6 (Hnf6) is
necessary for proper development of islet β-cells. Hnf6 is initially expressed
throughout the pancreatic epithelium but is downregulated in endocrine ... Cited by 4 - Related articles - BL Direct - All 6 versions
Y Wang, H Feng, C Bi, L Zhu, JW Pollard, B … - FEBS letters, 2007 - Elsevier We report that glycogen synthase kinase (GSK)-3β is phosphorylated at ser9 and
inactivated in uterine epithelial cells from E 2 -treated cyclin D1 null mutant
mice. Simultaneous administration of P 4 together with E 2 blocked this ... Cited by 4 - Related articles - All 6 versions
- ►diabetesjournals.org ZV Wang, J Mu, TD Schraw, L Gautron, JK … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—Islet transplantations have been performed clinically, but their
practical applications are limited. An extensive effort has been made toward the
identification of pancreatic β-cell stem cells that has yielded many ... Cited by 4 - Related articles - All 4 versions
