- ►diabetesjournals.org IR Lanza, DK Short, KR Short, S Raghavakaimal, R … - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS— Insulin sensitivity was measured by
hyperinsulinemic-euglycemic clamp and ATP production in mitochondria isolated from vastus
lateralis biopsies of 42 healthy sedentary and endurance-trained young (18–30 years ... Cited by 15 - Related articles - All 4 versions
L Jin, H Galonek, K Israelian, W Choy, M Morrison, Y … - Protein Sci, 2009 - interscience.wiley.com SIRT3 is a key mitochondrial protein deacetylase proposed to play key roles in regulating mitochondrial
metabolism but there has been considerable debate about its actual size, the sequences required
for activity, and its subcellular localization. A previously cloned mouse SIRT3 has high ... Cited by 4 - Related articles - All 3 versions
IK Law, L Liu, A Xu, KS Lam, PM Vanhoutte, CM … - Proteomics, 2009 - interscience.wiley.com Sirtuins are a family of NAD + -dependent protein deacetylases that regulate cellular functions
through deacetylation of a wide range of protein targets. Overexpression of Sir2, the first gene
discovered in this family, is able to extend the life span in various organisms. The ... Cited by 4 - Related articles - All 2 versions
H Cooper, J Spelbrink - Biochem. J, 2008 - biochemj.org It has recently been suggested that perhaps as many as 20% of all mitochondrial proteins are
regulated through lysine acetylation while SIRT3 has been implicated as an important mitochondrial
protein deacetylase. It is therefore of crucial importance that the mitochondrial localization ... Cited by 19 - Related articles - Cached - BL Direct - All 5 versions
C Schlicker, M Gertz, P Papatheodorou, B Kachholz … - Journal of Molecular …, 2008 - Elsevier The enzymes of the Sirtuin family of nicotinamide-adenine-dinucleotide-dependent protein deacetylases
are emerging key players in nuclear and cytosolic signaling, but also in mitochondrial regulation
and aging. Mammalian mitochondria contain three Sirtuins, Sirt3, Sirt4, and Sirt5. Only ... Cited by 20 - Related articles - All 3 versions
- ►pnas.org BH Ahn, HS Kim, S Song, IH Lee, J Liu, A … - Proceedings of the …, 2008 - National Acad Sciences Here, we demonstrate a role for the mitochondrial NAD-dependent deacetylase Sirt3 in the maintenance
of basal ATP levels and as a regulator of mitochondrial electron transport. We note that Sirt3
−/− mouse embryonic fibroblasts have a reduction in basal ATP levels. Reconstitution ... Cited by 22 - Related articles - All 6 versions
T Nakagawa, DJ Lomb, MC Haigis, L Guarente - Cell, 2009 - Elsevier Sirtuins are NAD-dependent protein deacetylases that connect metabolism and aging. In
mammals, there are seven sirtuins (SIRT1-7), three of which are associated with
mitochondria. Here, we show that SIRT5 localizes in the mitochondrial matrix and ... Cited by 11 - Related articles - All 5 versions
- ►cnfindpark.cn IR Lanza, KS Nair - American Journal of Clinical Nutrition, 2009 - Am Soc Nutrition Aging has been reported to be accompanied by reduced mitochondrial function and insulin
sensitivity. Whether these deleterious effects result from chronological age or lifestyle-related
factors such as adiposity and physical inactivity remains debatable. The beneficial effects ... Cited by 9 - Related articles - All 6 versions
IR Lanza, KS Nair - … Function, Part B: Mitochondrial Protein Kinases, …, 2009 - books.google.com > CHAPTER TWENTY Functional Assessment of Isolated Mitochondria In Vitro Ian R. Lanza
and K. Sreekumaran Nair Contents 1. Introduction 350 2. Mitochondrial Isolation Procedures
354 2.1. Tissue homogenization 355 2.2. Separation of mitochondria by differential ... Cited by 1 - Related articles - All 2 versions
AM Distler, J Kerner, K Lee, CL Hoppel - Methods in Enzymology, 2009 - Elsevier In recent years, a wide variety of proteomic approaches using gel electrophoresis and mass
spectrometry has been developed to detect post-translational modifications. Mitochondria are
often a focus of these studies due to their important role in cellular function. Many of their ... Cited by 2 - Related articles - All 4 versions
