- ►diabetesjournals.org P Fiorina, A Vergani, S Dada, M Jurewicz, M Wong, K … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Anti-CD22/cal monoclonal antibody (mAb) therapy resulted in early and prolonged
B-cell depletion and delayed disease in pre-diabetic mice. Importantly, when new-onset hyperglycemic
mice were treated with the anti-CD22/cal mAb, 100% of B-cell–depleted mice became ... Cited by 7 - Related articles - All 4 versions
G Zekavat, SY Rostami, A Badkerhanian, RF … - The Journal of …, 2008 - Am Assoc Immnol B lymphocytes are required for the pathogenesis of autoimmune diabetes in NOD mice. Previous
studies established that a lymphopenic transitional (TR) B cell compartment reduces the competitive
constraint on the entry of newly emerging TR B cells into the splenic follicle (FO), thereby ... Cited by 6 - Related articles - All 4 versions
- ►jimmunol.org Y Xiu, CP Wong, JD Bouaziz, Y Hamaguchi, … - The Journal of …, 2008 - Am Assoc Immnol NOD mice deficient for B lymphocytes from birth fail to develop autoimmune or type 1
diabetes. To assess whether B cell depletion influences type 1 diabetes in mice with an intact
immune system, NOD female mice representing early and late preclinical stages of ... Cited by 17 - Related articles - All 3 versions
- ►jimmunol.org Y Li, F Chen, M Putt, YK Koo, M Madaio, JC … - The Journal of …, 2008 - Am Assoc Immnol MRL/lpr mice develop a spontaneous systemic lupus erythematosus-like autoimmune syndrome
due to a dysfunctional Fas receptor, with contributions from other less well-defined genetic
loci. The removal of B cells by genetic manipulation not only prevents autoantibody ... Cited by 6 - Related articles - All 3 versions
- ►rexnealsmith.com [PDF] P Fiorina, M Jurewicz, A Augello, A Vergani, … - The Journal of …, 2009 - Am Assoc Immnol Human clinical trials in type 1 diabetes (T1D) patients using mesenchymal stem cells (MSC)
are presently underway without prior validation in a mouse model for the disease. In response
to this void, we characterized bone marrow-derived murine MSC for their ability to ... Related articles - All 5 versions
SK O'Neill, E Liu, JC Cambier - Current Opinion in Endocrinology, …, 2009 - journals.lww.com Introduction The failure to find a cure for type 1 diabetes has led to the exploration of efficacious
immunotherapies already approved for other diseases. A recent TrialNet study exploring the
use of rituximab in new onset type 1 dia- betics has been completed with positive ... Related articles - All 2 versions
HHM Abdu-Allah, K Watanabe, K Hayashizaki, Y … - Tetrahedron Letters, 2009 - Elsevier Synthetic ligands tagged with biotin have frequently been utilized to detect, localize, characterize
and recover the target protein. 4 Moreover, in order to pursue CD22 as a drug target, precise
and reproducible binding assays need to be developed. To address this goal we ... Related articles
PL Kendall, DJ Moore, C Hulbert, KL Hoek, … - The Journal of …, 2009 - Am Assoc Immnol Type 1 diabetes results from T cell-mediated destruction of insulin-producing ß cells. Although
elimination of B lymphocytes has proven successful at preventing disease, modulation of B cell
function as a means to prevent type 1 diabetes has not been investigated. The ... Related articles - All 3 versions
SL Cox, PA Silveira - Expert Review of Clinical Immunology, 2009 - ingentaconnect.com Type 1 diabetes (T1D) is caused by immune infiltration of the pancreatic islets of Langerhans
(referred to as insulitis) followed by specific auto- immune-mediated destruction of the
insulin- secreting b-cells within them [1] . Predisposition to T1D depends on the ... Related articles - All 3 versions
JK Whitmire, MS Asano, SM Kaech, S Sarkar, … - The Journal of …, 2009 - Am Assoc Immnol B cells can influence T cell responses by directly presenting Ag or by secreting Ab that binds
to Ag to form immunogenic complexes. Conflicting evidence suggests that persisting Ag-Ab complexes
propagate long-term T cell memory; yet, other data indicate that memory cells can survive ... Cited by 1 - Related articles - All 2 versions
