- ►diabetesjournals.org LG Moss, CJ Rhodes - Diabetes, 2007 - Am Diabetes Assoc It is now appreciated that both type 1 and type 2 diabetes are diseases of ß-cell insufficiency.
As such, there is a good deal of interest in mechanisms of ß-cell regeneration that hold some
therapeutic potential (1). This could apply to increasing numbers of remaining ... Cited by 1 - Related articles - BL Direct - All 4 versions
D Yin, J Tao, DD Lee, J Shen, M Hara, J Lopez, A … - Diabetes, 2006 - Am Diabetes Assoc Limitations in islet β-cell transplantation as a therapeutic option for type 1 diabetes have prompted
renewed interest in islet regeneration as a source of new islets. In this study we tested whether
severely diabetic adult C57BL/6 mice can regenerate β-cells. Diabetes was induced in ... Cited by 9 - Related articles - BL Direct - All 4 versions
I Cozar-Castellano, KK Takane, R Bottino, AN … - Diabetes, 2004 - Am Diabetes Assoc A lthough it is currently very clear that -cells can replicate, albeit slowly, in vitro and in vivo, both
basally and in response to a variety of maneuvers and stimuli (rev. in 1–3), the key components
of the cell cycle machinery in the -cell and the factors that regulate them are poorly ... Cited by 2 - Related articles - All 2 versions
SJ Salpeter, Y Dor - Pancreatic Beta Cell in Health and Disease, 2007 - Springer Summary. Patients suffering from type 1and type 2diabetes exhibit a decrease in the mass of
insulin-producing beta cells. Both the ability to generate and expand large amounts of transplantable
beta cells and the capacity to encour- age beta-cell proliferation in the patient represent ... Related articles - All 2 versions
- ►diabetesjournals.org I Cozar-Castellano, M Haught, AF Stewart - Diabetes, 2006 - Am Diabetes Assoc The rate of pancreatic β-cell replication is extremely slow. For example, Finegood et al. (1) report
that 3% of rodent β-cells replicate every 24 h. Kushner and colleagues (2) have recently reported
that in older mice, this rate is even slower, in the range of 0.07% of β-cells per 24 h. Butler ... Cited by 11 - Related articles - BL Direct - All 5 versions
T Animals, PCR Standard, Q Real-Time-PCR - Am Diabetes Assoc Transgenic Animals. Transgenic Pdx1cre, Ins2cre and Z/EG offspring were genotyped by tail
biopsy genomic DNA PCR using Platinum Taq DNA Polymerase (Invitrogen, Carlsbad, CA) with
the GAPDH, Z/EG, Ins2cre and Pdx1cre primer sets (See Supplemental Table 1.), as per ... Related articles
- ►diabetesjournals.org RC Vasavada, I Cozar-Castellano, D Sipula, AF … - Diabetes, 2007 - Am Diabetes Assoc Animal studies show that G 1/S regulatory molecules (D-cyclins, cdk-4, p18, p21, p27) are critical
for normal regulation of β-cell proliferation, mass, and function. The retinoblastoma protein,
pRb, is positioned at the very end of a cascade of these regulatory proteins and is ... Cited by 12 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org L Rachdi, N Balcazar, L Elghazi, DJ Barker, I Krits, H … - Diabetes, 2006 - Am Diabetes Assoc The steps controlling entry and progression through G 1 are dependent on cell type and
context. Little is known about the cell cycle in β-cells, but recent work from several laboratories
has shown that cyclin-dependent kinase-4 (cdk4) and cyclins D1 and D2 are critical ... Cited by 12 - Related articles - BL Direct - All 5 versions
LG Chase, F Ulloa-Montoya, BL Kidder, CM Verfaillie - Diabetes, 2007 - Am Diabetes Assoc As recent studies suggest that newly formed pancreatic β-cells are a result of self-duplication
rather than stem cell differentiation, in vitro expansion of β-cells presents a potential mechanism
by which to increase available donor tissue for cell-based diabetes therapies. Although ... Cited by 42 - Related articles - BL Direct - All 7 versions
- ►nih.gov JL Brockman, LA Schuler - Molecular and cellular endocrinology, 2005 - Elsevier Prolactin (PRL) modulates proliferation in the mammary gland and other tissues, in part through
inducing transcription of cyclin D1, a key regulator of G 1 phase cell cycle progression. We showed
previously that PRL, via Jak2, induces binding of Stat5 to a distal GAS site (GAS1) in the ... Cited by 14 - Related articles - All 4 versions
