SA Litherland - Diabetes, 2008 - Am Diabetes Assoc Autoimmune type 1 diabetes is caused by an interactive combination of genetic and environmental
factors, most of which remain unknown. Each individual appears to have a unique combination
of these factors that allow for their susceptibility to disease. Investigators have long ... Cited by 1 - Related articles - All 4 versions
C Ionescu - Diabetic Medicine - interscience.wiley.com An analysis of the last 20 000 newly diagnosed diabetic patients consecutively registered from
1 January 1981 to 6 June 1991 in the Bucharest Registry of Diabetes showed the following:
(1) primary insulin-dependence (Type 1 diabetes) was encountered in only 7% of cases: ... Cited by 4 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org K Tsuji-Takayama, M Suzuki, M Yamamoto, … - The Journal of …, 2008 - Am Assoc Immnol STAT5 molecules are key components of the IL-2 signaling pathway, the deficiency of which
often results in autoimmune pathology due to a reduced number of CD4 + CD25 + naturally occurring
regulatory T (Treg) cells. One of the consequences of the IL-2-STAT5 signaling axis is up- ... Cited by 5 - Related articles - All 2 versions
YH Van, WH Lee, S Ortiz, MH Lee, HJ Qin, CP Liu - Diabetes, 2009 - Am Diabetes Assoc RESULTS—Our data demonstrated that ATRA treatment inhibited diabetes in NOD mice with
established insulitis. In addition, it suppressed interferon (IFN)-γ–producing CD4 + and CD8
+ T effector (Teff) cells and expanded T regulatory (Treg) cells in recipient mice ... Cited by 4 - Related articles - All 3 versions
M Oikarinen, S Tauriainen, T Honkanen, K Vuori, P … - Diabetologia, 2008 - Springer Page 1. ARTICLE Analysis of pancreas tissue in a child positive for islet cell antibodies M.
Oikarinen & S. Tauriainen & T. Honkanen & K. Vuori & P. Karhunen & C. Vasama-Nolvi & S.
Oikarinen & C. Verbeke & GE Blair & I. Rantala & J. Ilonen & O. Simell & M. Knip & H. Hyöty ... Cited by 4 - Related articles - All 3 versions
F Miao, DD Smith, L Zhang, A Min, W Feng, R … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—A subset of genes in the type 1 diabetic cohort showed significant increase in H3K9me2
in lymphocytes but not in monocytes. CLTA4, a type 1 diabetes susceptibility gene, was one
of the candidates displaying increased promoter H3K9me2 in type 1 diabetes. IPA ... Cited by 3 - Related articles - All 4 versions
JS Allen, K Pang, A Skowera, R Ellis, C Rackham, B … - Diabetes, 2009 - Am Diabetes Assoc RESULTS—The balance of blood dendritic cells was profoundly disturbed at diabetes
diagnosis, with a significantly elevated proportion of plasmacytoid and reduction of myeloid cells
compared with control subjects. Dendritic cell subset distribution was normal in long- ... Cited by 6 - Related articles - All 3 versions
- ►jimmunol.org CQ Nguyen, J Gao, H Kim, DR Saban, JG … - The Journal of …, 2007 - Am Assoc Immnol NOD.B10-H2 b and NOD/LtJ mice manifest, respectively, many features of primary and secondary
Sjögren's syndrome (SjS), an autoimmune disease affecting primarily the salivary and lacrimal
glands leading to xerostomia (dry mouth) and xerophthalmia (dry eyes). B lymphocytes ... Cited by 6 - Related articles - All 4 versions
J Kronborg, SH Johnsen, I Njølstad, I Toft, BO Eriksen, … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis Proinsulin is increased in persons at cardiovascular risk. Increased
secretion of proinsulin relative to insulin has been suggested as a sign of defective conversion
of proinsulin to insulin and C-peptide and is associated with beta cell dysfunction. It has ... Cited by 5 - Related articles - BL Direct - All 4 versions
M von Herrath - Diabetes, 2009 - Am Diabetes Assoc We will take a journey from basic pathogenetic mechanisms elicited by viral infections that play
a role in the development of type 1 diabetes to clinical interventions, where we will discuss novel
combination therapies. The role of viral infections in the development of type 1 diabetes is ... Cited by 8 - Related articles - All 10 versions
