DR Cavener - Diabetes, 2009 - Am Diabetes Assoc In all cell types of the body, save one, the insulin gene is quiescent and is ensconced in a compact
and protected environment of chromatin. How the insulin gene is coaxed out of its chromatin
slumber in the pancreatic β-cell is unknown. Moreover, this question is of practical ... Cited by 1 - Related articles - All 4 versions
TG Deering, T Ogihara, AP Trace, B Maier, RG Mirmira - Diabetes, 2009 - Am Diabetes Assoc RESULTS—Within the pancreas, Set7/9 protein shows striking specificity for islet cells, including
α- and β-cells, as well as occasional cells within ducts. Consistent with these findings, the
Set7/9 gene promoter contained an islet-specific enhancer located between −5,768 and − ... Cited by 7 - Related articles - All 3 versions
YH Van, WH Lee, S Ortiz, MH Lee, HJ Qin, CP Liu - Diabetes, 2009 - Am Diabetes Assoc RESULTS—Our data demonstrated that ATRA treatment inhibited diabetes in NOD mice with
established insulitis. In addition, it suppressed interferon (IFN)-γ–producing CD4 + and CD8
+ T effector (Teff) cells and expanded T regulatory (Treg) cells in recipient mice ... Cited by 4 - Related articles - All 3 versions
C Ionescu - Diabetic Medicine - interscience.wiley.com An analysis of the last 20 000 newly diagnosed diabetic patients consecutively registered from
1 January 1981 to 6 June 1991 in the Bucharest Registry of Diabetes showed the following:
(1) primary insulin-dependence (Type 1 diabetes) was encountered in only 7% of cases: ... Cited by 4 - Related articles - BL Direct - All 4 versions
M Oikarinen, S Tauriainen, T Honkanen, K Vuori, P … - Diabetologia, 2008 - Springer Page 1. ARTICLE Analysis of pancreas tissue in a child positive for islet cell antibodies M.
Oikarinen & S. Tauriainen & T. Honkanen & K. Vuori & P. Karhunen & C. Vasama-Nolvi & S.
Oikarinen & C. Verbeke & GE Blair & I. Rantala & J. Ilonen & O. Simell & M. Knip & H. Hyöty ... Cited by 4 - Related articles - All 3 versions
JS Allen, K Pang, A Skowera, R Ellis, C Rackham, B … - Diabetes, 2009 - Am Diabetes Assoc RESULTS—The balance of blood dendritic cells was profoundly disturbed at diabetes
diagnosis, with a significantly elevated proportion of plasmacytoid and reduction of myeloid cells
compared with control subjects. Dendritic cell subset distribution was normal in long- ... Cited by 6 - Related articles - All 3 versions
J Kronborg, SH Johnsen, I Njølstad, I Toft, BO Eriksen, … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis Proinsulin is increased in persons at cardiovascular risk. Increased
secretion of proinsulin relative to insulin has been suggested as a sign of defective conversion
of proinsulin to insulin and C-peptide and is associated with beta cell dysfunction. It has ... Cited by 5 - Related articles - BL Direct - All 4 versions
GL Zhou, DP Liu, CC Liang - Bioessays, 2005 - interscience.wiley.com The developmental programs of eukaryotic organisms involve the programmed transcription
of genes. A characteristic gene expression pattern is established and preserved in each different
cell type. Therefore, gene activation at a particular time and its maintenance during cell ... Cited by 6 - Related articles - BL Direct - All 5 versions
M von Herrath - Diabetes, 2009 - Am Diabetes Assoc We will take a journey from basic pathogenetic mechanisms elicited by viral infections that play
a role in the development of type 1 diabetes to clinical interventions, where we will discuss novel
combination therapies. The role of viral infections in the development of type 1 diabetes is ... Cited by 8 - Related articles - All 10 versions
CM Filippi, MG von Herrath - Diabetes, 2008 - Am Diabetes Assoc The most popular hypothesis circulating within and beyond the scientific community is that viral
infections enhance or elicit autoimmune disorders such as type 1 diabetes. Indeed, viruses can
injure β-cells and have been isolated in pancreatic tissues from diabetic patients. ... Cited by 8 - Related articles - All 8 versions
