DA Jacobson, BL Wicksteed, LH Philipson - Diabetes, 2009 - Am Diabetes Assoc The α-cell of the pancreatic islet modulates glucose homeostasis by secreting glucagon that
acts primarily by driving hepatic glucose production. Glucose sensing of the α-cell becomes defective
in both type 1 and type 2 diabetes, resulting in hyperglucagonemia that likely contributes ... Related articles - All 4 versions
- ►diabetesjournals.org N Quoix, R Cheng-Xue, L Mattart, Z Zeinoun, Y Guiot, … - Diabetes, 2009 - Am Diabetes Assoc RESULTS—In 0.5 mmol/l glucose, [Ca 2+ ] c oscillated in some -cells and was basal in the
others. Increasing glucose to 15 mmol/l decreased [Ca 2+ ] c by 30% in oscillating cells and was
ineffective in the others. -Cell I KATP was inhibited by tolbutamide and activated by ... Cited by 1 - Related articles - All 3 versions
YM Leung, I Ahmed, L Sheu, RG Tsushima, NE … - … and Biophysical Research …, 2006 - Elsevier In low or absence of glucose, α-cells generate rhythmic action potentials and secrete
glucagon. α-Cell T-type Ca 2+ channels are believed to be pacemaker channels, which are expected
to open near the resting membrane potential (around −60 mV) to initiate a small ... Cited by 9 - Related articles - All 5 versions
PE MacDonald, YZ De Marinis, R Ramracheya, A … - PLoS Biology, 2007 - ukpmc.ac.uk Glucagon, secreted from pancreatic islet α cells, stimulates gluconeogenesis and liver glycogen
breakdown. The mechanism regulating glucagon release is debated, and variously attributed
to neuronal control, paracrine control by neighbouring β cells, or to an intrinsic glucose ... Related articles - All 2 versions
PE MacDonald, YZ De Marinis, R Ramracheya, A … - PLoS Biol, 2007 - biology.plosjournals.org Glucagon, secreted from pancreatic islet α cells, stimulates gluconeogenesis and liver glycogen
breakdown. The mechanism regulating glucagon release is debated, and variously attributed
to neuronal control, paracrine control by neighbouring β cells, or to an intrinsic glucose ... Cited by 26 - Related articles - Cached - All 7 versions
Y Zhang, N Zhang, AV Gyulkhandanyan, E Xu, HY … - Diabetologia, 2008 - Springer Abstract Aims/hypothesis The hyperpolarisation-activated cyclic nucleotide-gated (HCN)
channels, discovered initially in cardiac and neuronal cells, mediate the inward pacemaker current
(I f or I h ). Recently, we have demonstrated the presence of HCN channels in pancreatic ... Cited by 1 - Related articles - All 2 versions
- ►cell.com P Rorsman, SA Salehi, F Abdulkader, M Braun, PE … - Trends in Endocrinology & …, 2008 - Elsevier Glucagon, secreted by the α-cells of the pancreatic islets, is the most important glucose-increasing
hormone of the body. The precise regulation of glucagon release remains incompletely defined
but has been proposed to involve release of inhibitory factors from neighbouring β-cells ( ... Cited by 4 - Related articles - All 5 versions
- ►endojournals.org HL Olsen, S Theander, K Bokvist, K Buschard, CB … - Endocrinology, 2005 - Endocrine Soc In isolated rat pancreatic -cells, glucose, arginine, and the sulfonylurea tolbutamide stimulated
glucagon release. The effect of glucose was abolished by the K ATP -channel opener diazoxide
as well as by mannoheptulose and azide, inhibitors of glycolysis and mitochondrial ... Cited by 43 - Related articles - BL Direct - All 5 versions
W Qinghua, L LEITER, G BOOTH, A CHENG, P … - endocrinologyrounds.ca Diabetes is the leading cause of death from disease in North America and, in Canada alone,
over 2 million people have diabetes. Hyperglycemia is the characteristic sign of diabetes and
a predominant cause of the development of the long-term com- plications associated with ... Related articles - View as HTML
