- ►diabetesjournals.org G Boden - Diabetes, 2009 - Am Diabetes Assoc Obesity, which has reached epidemic proportions in the US and is increasing worldwide, is closely
associated with insulin resistance (peripheral and hepatic) and with a state of low-grade
inflammation, the latter characterized by elevated levels of proinflammatory cytokines in ... Related articles - All 3 versions
- ►diabetesjournals.org MF Gregor, L Yang, E Fabbrini, BS Mohammed, JC … - Diabetes, 2009 - Am Diabetes Assoc RESULTS—Subjects lost 39 ± 9% body wt at 1 year after GBP surgery (P < 0.001), which was
associated with a marked improvement in hepatic, skeletal muscle, and adipose tissue insulin
sensitivity. Markers of ER stress in adipose tissue significantly decreased with weight ... Cited by 10 - Related articles - All 4 versions
G Boden - Endocrinology and metabolism clinics of North …, 2008 - pubmedcentral.nih.gov Obesity is closely associated with (peripheral as well as hepatic) insulin resistance (1) and with
a low grade state of inflammation characterized by elevation of proinflammatory cytokines in
blood and tissues (2). Both, insulin and inflammation, contribute to the development of ... Cited by 11 - Related articles - All 33 versions
- ►endojournals.org NK Sharma, SK Das, AK Mondal, OG Hackney, … - Journal of Clinical …, 2008 - Endocrine Soc Results: Adipocyte expression of most markers of ER stress, including chaperones downstream
of activating transcription factor 6, were significantly correlated with BMI and percent fat (r >
0.5; P < 0.00001). Phosphorylation of eukaryotic initiation factor 2 but not of c-Jun ... Cited by 12 - Related articles - All 4 versions
- ►diabetesjournals.org G Boden, X Duan, C Homko, EJ Molina, WW Song, O … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Proteomic analysis revealed 19 differentially upregulated proteins in fat of obese
subjects. Three of these proteins were the ER stress–related unfolded protein response
(UPR) proteins calreticulin, protein disulfide-isomerase A3, and glutathione-S-transferase ... Cited by 24 - Related articles - All 5 versions
- ►physiology.org E Lai, G Bikopoulos, MB Wheeler, M … - American Journal of …, 2008 - Am Physiological Soc Chronic exposure to elevated saturated free fatty acid (FFA) levels has been shown to induce
endoplasmic reticulum (ER) stress that may contribute to promoting pancreatic β-cell
apoptosis. Here, we compared the effects of FFAs on apoptosis and ER stress in human ... Cited by 19 - Related articles - BL Direct - All 3 versions
GS Hotamisligil - International Journal of Obesity, 2008 - nature.com Obesity is associated with chronic low-grade inflammation. Inflammatory signals interfere with
insulin action and disrupt metabolic homeostasis. The c-Jun N-terminal kinase (JNK) has been
identified as a central mediator of insulin resistance. Recent studies showed that in ... Cited by 1 - Related articles - All 3 versions
HL Kammoun, I Hainault, P Ferré, F … - Current Opinion in Clinical …, 2009 - journals.lww.com Introduction Nonalcoholic fatty liver diseases (NAFLD) are emerging diseases closely linked
to the progression of obesity and type 2 diabetes and are now considered as the hepatic side
of the metabolic syndrome. NAFLD include several path- ologies originating from ... Cited by 1 - Related articles - All 6 versions
