- ►diabetesjournals.org AL Gloyn, M Braun, P Rorsman - Diabetes, 2009 - Am Diabetes Assoc Type 2 diabetes is associated with impaired insulin secretion. Both 1st- and 2nd-phase insulin
secretion are reduced, but the effect is particularly pronounced for the 1st phase. The processes
culminating in impaired insulin secretion are not fully understood, but both genetic and ... Cited by 2 - Related articles - All 3 versions
- ►jhc.org D Tornehave, P Kristensen, J Romer, LB … - … of Histochemistry and …, 2008 - Histochemical Soc GLP-1 acts through a G protein–coupled receptor (GLP-1R) (Thorens 1992 Go ), which is expressed
in several tissues including the pancreatic islets (Bullock et al. 1996 Go ). Using radioligand binding
assays, GLP-1Rs have been identified on multiple lines of pancreatic β cells and a ... Cited by 5 - Related articles - All 5 versions
P Butler - Novartis Foundation symposium, 2000 - ncbi.nlm.nih.gov Insulin is secreted in a pulsatile manner. Recently it has been shown that almost all (approximately
70-100%) of insulin is secreted in discrete insulin secretory bursts occurring approximately every
6 min. Furthermore, it has been revealed that regulation of the rate of insulin secretion is ... Cited by 5 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org G da Silva Xavier, MK Loder, A McDonald, AI Tarasov, … - Diabetes, 2009 - Am Diabetes Assoc OBJECTIVE Polymorphisms in the human TCF7L2 gene are associated with reduced insulin
secretion and an increased risk of type 2 diabetes. However, the mechanisms by which TCF7L2
affect insulin secretion are still unclear. We define the effects of TCF7L2 expression level ... Cited by 10 - Related articles - All 3 versions
MA Nauck, JJ Meier - Diabetologia, 2007 - Springer Page 1. COMMENTARY The enteroinsular axis may mediate the diabetogenic effects of TCF7L2
polymorphisms MA Nauck & JJ Meier Published online: 27 September 2007 # Springer-Verlag
2007 Keywords Beta cell function . Beta cell mass . Diabetes genes . ... Cited by 10 - Related articles - BL Direct - All 2 versions
S Piteau, A Olver, SJ Kim, K Winter, JA Pospisilik, F … - … and Biophysical Research …, 2007 - Elsevier In type 2 diabetes (T2DM) β-cell responsiveness to glucose-dependent insulinotropic polypeptide
(GIP) is reduced. In a model of T2DM, the VDF Zucker rat, GIP receptor mRNA and protein levels
were shown to be down-regulated. Possible restoration of responsiveness to GIP in ... Cited by 12 - Related articles - All 4 versions
A Wiederkehr, CB Wollheim - Cell Calcium, 2008 - Elsevier Mitochondria play an essential role in metabolism-secretion coupling in the pancreatic
β-cell. Dysfunction of the organelle leads to impaired glucose-stimulated insulin secretion, as
exemplified by the rare disease mitochondrial diabetes, which is caused by mutations in ... Cited by 16 - Related articles - All 3 versions
[CITATION] Diabetes mellitus and exocrine pancreatic dysfunction in perk2/2 mice reveals a …
- ►endojournals.org NS Sauter, FT Schulthess, R Galasso, LW Castellani, K … - Endocrinology, 2008 - Endocrine Soc Subclinical inflammation is a recently discovered phenomenon in type 2 diabetes. Elevated cytokines
impair β-cell function and survival. A recent clinical trial shows that blocking IL-1β signaling by
IL-1 receptor antagonist (IL-1Ra) improves β-cell secretory function in patients with type 2 ... Cited by 19 - Related articles - BL Direct - All 4 versions
