- ►diabetesjournals.org T Alquier, V Poitout - Diabetes, 2009 - Am Diabetes Assoc Since its deorphanization in 2003 (1,2), the fatty acid receptor GPR40 (FFAR1/FFA1) has drawn
considerable attention as a potential therapeutic target for type 2 diabetes. Because fatty acids
acutely amplify insulin secretion only in the presence of glucose, the discovery of a “ ... Cited by 2 - Related articles - All 3 versions
- ►diabetesjournals.org K Nagasumi, R Esaki, K Iwachidow, Y Yasuhara, K Ogi, … - Diabetes, 2009 - Am Diabetes Assoc RESULTS In comparison with nontransgenic littermates, hGPR40 transgenic mice exhibited
improved oral glucose tolerance with an increase in insulin secretion. Although islet morphologic
analysis showed no obvious differences between hGPR40 transgenic and nontransgenic ... Cited by 8 - Related articles - All 4 versions
DS Luciani, KS Gwiazda, TLB Yang, TB Kalynyak, Y … - Diabetes, 2009 - Am Diabetes Assoc RESULTS—Neither RyR nor IP 3 R inhibition, alone or in combination, caused robust death
within 24 h. In contrast, blocking sarco/endoplasmic reticulum ATPase (SERCA) pumps depleted
ER Ca 2+ and induced marked phosphorylation of PKR-like ER kinase (PERK) and ... Cited by 3 - Related articles - All 3 versions
- ►oxfordjournals.org [PDF] R Ashworth, C Brennan - Briefings in Functional Genomics and …, 2005 - Oxford Univ Press Rachel Ashworth is a BBSRC research fellow in the Department of Physiology, University College
London, London. Caroline Brennan is group leader in the Department of Cell Signalling and
Development, School of Biological Sciences, Queen Mary University of London, London. Cited by 3 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org AV Matveyenko, T Gurlo, M Daval, AE Butler, PC Butler - Diabetes, 2009 - Am Diabetes Assoc OBJECTIVE Obesity is a known risk factor for type 2 diabetes. However, most obese individuals
do not develop diabetes because they adapt to insulin resistance by increasing β-cell mass and
insulin secretion. Islet pathology in type 2 diabetes is characterized by β-cell loss, islet ... Cited by 3 - Related articles - All 3 versions
- ►physiology.org Y Tian, RF Corkey, GC Yaney, PB Goforth, … - American Journal of …, 2008 - Am Physiological Soc Nonesterified fatty acids such as oleate and palmitate acutely potentiate insulin secretion from
pancreatic islets in a glucose-dependent manner. In addition, recent studies show that fatty acids
elevate intracellular free Ca 2+ and increase voltage-gated Ca 2+ current in mouse ... Cited by 3 - Related articles - All 4 versions
JE McCombs, AE Palmer - Methods, 2008 - Elsevier Genetically encoded calcium indicators (GECIs) allow researchers to measure calcium dynamics
in specific targeted locations within living cells. Such indicators enable dissection of the spatial
and temporal control of calcium signaling processes. Here we review recent progress in ... Cited by 5 - Related articles - All 2 versions
ML Peyot, C Guay, MG Latour, J Lamontagne, R … - Journal of Biological …, 2009 - ASBMB Reduced lipolysis in hormone-sensitive lipase-deficient mice is associated with impaired
glucose-stimulated insulin secretion (GSIS), suggesting that endogenous β-cell lipid stores provide
signaling molecules for insulin release. Measurements of lipolysis and triglyceride (TG) ... Cited by 4 - Related articles - All 4 versions
- ►endojournals.org J Cornish, A MacGibbon, JM Lin, M Watson, KE Callon, … - Endocrinology, 2008 - Endocrine Soc Clinical studies have shown that total body fat mass is related to both bone density and fracture
risk and that fat ingestion reduces bone turnover. These effects are at least partially mediated
by endocrine mechanisms, but it is possible that lipids might act directly on bone. We ... Cited by 4 - Related articles - All 3 versions
A Tengholm, E Gylfe - Molecular and Cellular Endocrinology, 2009 - Elsevier Pancreatic β-cells possess an inherent ability to generate oscillatory signals that trigger insulin
release. Coordination of the secretory activity among β-cells results in pulsatile insulin secretion
from the pancreas, which is considered important for the action of the hormone in the ... Cited by 7 - Related articles - All 2 versions
