RT Kurmasheva, JB Easton, PJ Houghton - American Society of Clinical Oncology Educational …, 2008 - edbook.ascopubs.org Overview: Although conventional multimodality therapy is curative for most
patients diagnosed with nonmetastatic rhabdomyosarcoma (RMS), the survival rate
in children with metastatic disease has not improved significantly with the ... Related articles
- ►nih.gov J Zhan, JB Easton, S Huang, A Mishra, L … - Molecular and Cellular Biology, 2007 - Am Soc Microbiol The cyclin-dependent kinase inhibitor p21 Cip1 regulates multiple cellular
functions and protects cells from genotoxic and other cellular stresses.
Activation of apoptosis signal-regulating kinase 1 (ASK1) induced by ... Cited by 5 - Related articles - BL Direct - All 8 versions
AS Guerreiro, D Boller, KT Doepfner, A Arcaro - Drug News Perspect, 2006 - journals.prous.com As insulin-like growth factor (IGF) signaling has been recognized to play an
important role in human cancer, the IGF-I receptor (IGF-IR) is currently the
focus of intensive research aimed at developing novel antitumor agents. The ... Cited by 13 - Related articles - All 3 versions
RT Kurmasheva, L Dudkin, C Billups, LV … - Cancer Research, 2009 - AACR Deregulated insulin-like growth factor signaling through the type-1 receptor
(IGF-1R) appears common to many childhood solid tumors and offers an important
molecular target for developmental therapeutics. For example, the alveolar ... Related articles - All 2 versions
H Cam, H Griesmann, M Beitzinger, L Hofmann, … - Cancer Cell, 2006 - Elsevier The p53 family comprises the tumor suppressor p53 and the structural homologs
p63 and p73. How the three family members cooperate in tumor suppression remains
unclear. Here, we report different but complementary functions of the ... Cited by 23 - Related articles - All 9 versions
R Baserga - European Journal of Cancer, 2004 - Elsevier The existence of the type 1 insulin-like growth factor receptor (IGF-IR) had
been surmised for a number of years, before it was cloned in 1986 by Ullrich et
al. [1]. At that time, the IGF-IR was considered a poor relative of the ... Cited by 22 - Related articles - All 12 versions
- ►nih.gov RT Kurmasheva, PJ Houghton - Current opinion in chemical biology, 2007 - Elsevier Intensive use of cytotoxic agents in multimodality therapeutic regimens has
resulted in almost 80% five-year disease-free survival and cure in the majority
of childhood cancer patients. However, such success has come at the expense ... Cited by 6 - Related articles - All 3 versions
- ►pedpath.org S Makawita, M Ho, AD Durbin, PS Thorner, D … - Pediatric and Developmental Pathology, 2008 - pedpath.org Recent studies have shown a significant involvement of insulin-like growth
factor (IGF) signaling components in the pathogenesis of rhabdomyosarcoma (RMS).
Furthermore, there has been some evidence to indicate that differential ... Cited by 1 - Related articles - All 2 versions
EA Kolb, R Gorlick, PJ Houghton, CL Morton, … - Medical and Pediatric Oncology - interscience.wiley.com It is also possible that your web browser is not configured or not able to
display style sheets. In this case, although the visual presentation will be
degraded, the site should continue to be functional. We recommend using the ... Cited by 24 - Related articles - BL Direct - All 2 versions
D Sachdev, D Yee - Journal of mammary gland biology and neoplasia, 2006 - Springer Abstract The peptide growth factors IGF-I and IGF-II not only play a role in the
development of the mammary gland but are also implicated in breast cancer.
Several reagents disrupting IGF signaling have been developed and clinical ... Cited by 27 - Related articles - BL Direct - All 4 versions
