H Sagelius, Y Rosengardten, E Schmidt, C … - British Medical Journal, 2008 - jmg.bmj.com Hutchinson–Gilford progeria syndrome (HGPS) is a rare progeroid syndrome
caused by mutations in the LMNA gene. Currently there is no treatment available
for HGPS, but promising results from several studies using farnesyl ... Cited by 7 - Related articles - All 4 versions
- ►pnas.org BC Capell, M Olive, MR Erdos, K Cao, DA … - Proceedings of the National Academy of Sciences, 2008 - National Acad Sciences Hutchinson-Gilford progeria syndrome (HGPS) is the most dramatic form of human
premature aging. Death occurs at a mean age of 13 years, usually from heart
attack or stroke. Almost all cases of HGPS are caused by a de novo point ... Cited by 8 - Related articles - All 15 versions
- ►angrylapdog.com MA Merideth, LB Gordon, S Clauss, V Sachdev … - The New England journal of medicine, 2008 - content.nejm.org.p.angrylapdog.com Results Clinical investigations confirmed sclerotic skin, joint contractures,
bone abnormalities, alopecia, and growth impairment in all 15 patients;
cardiovascular and central nervous system sequelae were also documented. ... Cited by 32 - Related articles - Cached - BL Direct - All 7 versions
- ►oxfordjournals.org Y Wang, AA Panteleyev, DM Owens, K … - Human Molecular Genetics, 2008 - Oxford Univ Press Hutchinson–Gilford progeria syndrome (HGPS) is an accelerated aging disorder
caused by point mutation in LMNA encoding A-type nuclear lamins. The mutations
in LMNA activate a cryptic splice donor site, resulting in expression of a ... Cited by 4 - Related articles - All 6 versions
SH Yang, DA Andres, HP Spielmann, SG … - The Journal of Clinical Investigation, 2008 - pubmedcentral.nih.gov Hutchinson-Gilford progeria syndrome (HGPS), a rare disease that results in what
appears to be premature aging, is caused by the production of a mutant form of
prelamin A known as progerin. Progerin retains a farnesyl lipid anchor at ... Cited by 5 - Related articles - All 7 versions
MW Kieran, L Gordon, M Kleinman - Pediatrics, 2007 - Am Acad Pediatrics Progeria (Hutchinson-Gilford progeria syndrome) is a rare genetic disorder that
offers considerable insight into the biology of premature aging. This review
summarizes the clinical characteristics of this disease and the underlying ... Cited by 10 - Related articles - BL Direct - All 3 versions
- ►biologists.org H Sagelius, Y Rosengardten, M Hanif, MR … - Journal of Cell Science, 2008 - jcs.biologists.org Hutchinson-Gilford progeria syndrome (HGPS) is a rare human genetic disorder
characterized by striking progeroid features. Clinical findings in the skin
include scleroderma, alopecia and loss of subcutaneous fat. HGPS is usually ... Cited by 11 - Related articles - BL Direct - All 5 versions
J Wang, JF Robinson, CH O'Neil, JY Edwards, … - Journal of Human Genetics, 2006 - Springer Abstract Hutchinson-Gilford progeria syndrome (HGPS; MIM 176670) is a rare
disease characterized by accelerated aging. In this study, light and immuno-
fluorescence microscopy were used to assess morpho- logical changes, ... Cited by 6 - Related articles - BL Direct - All 6 versions
- ►nih.gov SH Yang, X Qiao, LG Fong, SG Young - BBA-Molecular and Cell Biology of Lipids, 2008 - Elsevier Hutchinson–Gilford progeria syndrome (HGPS) is a progeroid syndrome
characterized by multiple aging-like disease phenotypes. We recently reported
that a protein farnesyltransferase inhibitor (FTI) improved several disease ... Cited by 15 - Related articles - All 3 versions
KN Shah, HW Kaiser, J Hanfland - members.medscape.com Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare hereditary
disease that affects the skin, musculoskeletal system, and vasculature. HGPS is
characterized by signs of premature aging. The term progeria is derived ... Related articles - Cached - All 3 versions
