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Imipenem: first of a new class of beta-lactam antibiotics


M BARZA - Annals of internal medicine, 1985 - Am Coll Physicians
Imipenem, the first of a new class of carbapenem antibiotics, has potent activity against most
clinically important species of bacteria, including isolates resistant to other antibiotics. The drug
is well distributed to most tissues and fluids after intravenous administration; however, ...
Cited by 51 - Related articles - All 4 versions

A multiclinic randomized study of the comparative efficacy, safety and tolerance of …


GB Calandra, M Hesney, C Grad - European Journal of Clinical Microbiology & …, 1984 - Springer
Imipenem/cilastatin (MK0787/MK0791; N-formimi- doyl thienamcycin/inhibitor) is a broad-spectrum
carbapenem antibiotic with in vitro activity against almost all gram-positive and gram-negative
aerobic and anaerobic bacteria (1,2): In the first comparative clinical trials imipenem/ ...
Cited by 19 - Related articles - All 3 versions

Convulsions associated with sodium cefazolin: a case report.


RL Yost, JD Lee, JP O'Leary - The American surgeon, 1977 - ncbi.nlm.nih.gov
Our patient was severely injured, and had a prolonged period of hypotension. After operation
she received moderate doses of cefazolin, intravenously, in the face of acute renal failure. Seizures
associated with a serum cefazolin level of 455 mg/ml were observed. Although a cause ...
Cited by 20 - Related articles

Inhibitory effect of cephalosporins on gamma-aminobutyric acid receptor binding in …

- nih.gov [PDF] 
S Hori, S Kurioka, M Matsuda, J Shimada - Antimicrobial agents and …, 1985 - Am Soc Microbiol
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Apr. 1985, p. 650-651 ... Inhibitory Effect
of Cephalosporins on y-Aminobutyric Acid ... SEIJI HORI,l* SUSUMU KURIOKA,1 MAKOTO
MATSUDA,1 ... Department of Biochemistry' and Second Department ofInternal ...
Cited by 28 - Related articles - All 7 versions

Aminoglycoside antibiotics: resistance and toxicity: a summary


GG Jackson - Reviews of Infectious Diseases, 1983 - jstor.org
Three generations of aminoglycoside antibiotics have been produced for the purpose (and with
the net effect) of decreasing the prevalence of resistant bacterial strains and diminishing the
toxic effects of the drugs on the host. A considerable measure of success in the former ...
Cited by 8 - Related articles

Aztreonam: the first monobactam


RB Sykes, DP Bonner - The American Journal of Medicine, 1985 - Elsevier
A novel screening procedure led to isolation of the structurally unique, bacterially produced,
monocyclic beta-lactam antibiotics early in 1979. These naturally occurring “monobactams” were
not clinically useful as antibiotics because of their poor antibacterial properties. They ...
Cited by 32 - Related articles - All 2 versions

Animal model for evaluating the convulsive liability of beta-lactam antibiotics.

- nih.gov [PDF] 
PD Williams, DB Bennett, CR Comereski - Antimicrobial agents and …, 1988 - Am Soc Microbiol
Page 1. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, May 1988, p. 758-760 Vol. 32, No.
5 0066-4804/88/050758-03$02.00/0 Copyright © 1988, American Society for Microbiology Animal
Model for Evaluating the Convulsive Liability of 1-Lactam Antibiotics ...
Cited by 33 - Related articles - All 6 versions

Pneumonia treated with imipenem/cilastatin.


RA Salata, RL Gebhart, DL Palmer, BH Wade, … - The American journal of …, 1985 - ncbi.nlm.nih.gov
In an open, prospective, multicenter trial the efficacy and tolerance of imipenem/cilastatin for
the treatment of bacterial pneumonia was investigated. Forty-three adults were studied: 29 with
nosocomial and 14 with community-acquired infections. Significant underlying disease ...
Cited by 36 - Related articles

Metronidazole: in vitro activity, pharmacology and efficacy in anaerobic bacterial …


FP Tally, CE Sullivan - Pharmacotherapy - ncbi.nlm.nih.gov
Metronidazole is a 5-nitroimidazole that has selective activity against anaerobic
microorganisms, including bacteria and protozoa. Intravenous metronidazole has recently been
approved by the US Food and Drug Administration for the treatment of serious anaerobic ...
Cited by 15 - Related articles

Chloramphenicol.


JG Bartlett - Medical Clinics of North America, 1982 - csa.com
Chloramphenicol. JG Bartlett Medical Clinics of North America 66:11, 91-102, 1982.
Chloramphenicol is produced by an actinomycete, Streptomyces venezuelae , which
was initially found in soil sample in Venezuela in 1947. ...
Cited by 15 - Related articles - All 3 versions


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