… HJ ZIMMERMAN, E ADLER, SB BENJAMIN - Annals of internal …, 1986 - Am Coll Physicians We have treated 6 chronic alcoholics and identified an additional 19 reported in the literature
who developed severe hepatotoxicity from acetaminophen taken in apparently moderate
doses. The clinical disease in these 25 patients had a characteristic pattern: mild to ... Cited by 234 - Related articles - All 5 versions
HJ Zimmerman, WC Maddrey - Hepatology, 1995 - interscience.wiley.com Hepatic injury in alcoholics due to intake of acetaminophen (APAP or
acetylparaaminophenol) with therapeutic intent has been reported, but the extent of the phenomenon
is not clear, pertinent details of the association remain insufficiently clarified, and the ... Cited by 272 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] BH Lauterburg, ME Velez - British Medical Journal, 1988 - gut.bmj.com Patients chronically abusing ethanol are more susceptible to the hepatotoxic effects of paracetamol
such that relatively small doses of the analgesic may result in severe hepatic damage.'2 Animal
studies have shown that the toxicity of paracetamol arises as a consequence of the ... Cited by 134 - Related articles - All 7 versions
DC Whitcomb, GD Block - Jama, 1994 - Am Med Assoc OBJECTIVES--To evaluate the association of fasting and alcohol use with hepatotoxicity from
acetaminophen ingested for therapeutic reasons. DESIGN--Retrospective case series.
SETTING--Hospitals of the University of Pittsburgh (Pa) Medical Center. PATIENTS--A ... Cited by 292 - Related articles - BL Direct - All 5 versions
CJ McClain, JP Kromhout, FJ Peterson, JL Holtzman - Jama, 1980 - Am Med Assoc Severe liver failure developed in three chronic alcoholics after they ingested acetaminophen
for therapeutic reasons. The clinical course was characterized by SGOT levels of 5,000 to 10,000
IU. Concomitant renal failure developed in two of these patients, and one died in hepatic ... Cited by 109 - Related articles - All 3 versions
M Black - Annual review of medicine, 1984 - Annual Reviews This review of acetaminophen hepatotoxicity begins with a history of the drug and consideration
of the scope of its current use. The molecular basis for hepatotoxicity is discussed and this serves
as a background for delineation of its clinical manifestations and treatment. Although ... Cited by 232 - Related articles - All 7 versions
C Sato, Y Matsuda, CS Lieber - Gastroenterology, 1981 - ncbi.nlm.nih.gov This study was undertaken to evaluate the effects of chronic ethanol consumption on the hepatotoxicity
of acetaminophen. Male Sprague-Dawley rats were pair fed a nutritionally adequate liquid diet
containing either ethanol or isocaloric carbohydrate for 4-6 wk. Acetaminophen (0.5 g/kg ... Cited by 116 - Related articles - All 3 versions
AJ Makin, J Wendon, R Williams - Gastroenterology, 1995 - Elsevier Five hundred sixty patients admitted between January 1, 1987, and December 31, 1993, with
severe acetaminophen-induced hepatotoxicity were studied. The aim of this study was to identify
why severe acetaminophen-induced hepatotoxicity still occurs and to determine how ... Cited by 175 - Related articles - BL Direct - All 6 versions
