N KAPLOWITZ, TAKYEE AW, FR SIMON, A … - Annals of internal …, 1986 - Am Coll Physicians Drug-induced injury to the liver can mimic any form of acute or chronic liver disease. Acute injury
to the liver frequently is due to the action of cytochrome P450, which breaks down drugs into
electrophiles or free radicals; these reactive metabolites can covalently bind to protein ... Cited by 111 - Related articles - All 7 versions
S Sherlock - The Lancet, 1986 - Elsevier Drugs in common use can cause toxic effects on the liver which can mimic almost every naturally
occurring liver disease in man. Drugs can have direct (metabolite-related) toxic effects; they can
also cause deposition of microvesicular fat in hepatocytes; or they can provoke reactions ... Cited by 47 - Related articles - All 6 versions
RG Watson, A Olomu, D Clements, RH Waring, S … - Journal of …, 1988 - ncbi.nlm.nih.gov On the basis of previous experimental studies we postulated that individuals who were phenotypically
good hydroxylators but poor sulphoxidisers would be susceptible to chlorpromazine
jaundice. Sulphoxidation capacity was assessed in 12 subjects with a history of ... Cited by 30 - Related articles - All 2 versions
DE Johnston, C Kroening - Pharmacol Toxicol, 1998 - interscience.wiley.com Abstract: CCl 4 causes liver necrosis in a dose-dependent manner in vivo. However, we found
that primary rat hepatocytes in culture were killed after a 2 hr incubation with carbon tetrachloride
gas at CCl 4 partial pressures above a threshold between 45 and 54 mmHg. Below this ... Cited by 32 - Related articles - BL Direct - All 4 versions
A Shirkhoda, S Baird - Abdominal imaging, 1994 - Springer Abstract. Thirty patients with metastatic breast carcinoma to the liver underwent systemic
chemotherapy. Twenty- four of these patients also received hepatic arterial infusion
chemotherapy, three in conjunction with hepatic artery embolization. The morphologic ... Cited by 17 - Related articles - BL Direct - All 3 versions
[CITATION] Cell injury and cellular death
RS Cotran, V Kumar, SL Robbins - Robbin's Pathologic Basis of Disease, 5th Edition, …, 1994 Cited by 7 - Related articles
E Bajetta, R Buzzoni, R Giardini, G Bonadonna - Tumori, 1981 - ncbi.nlm.nih.gov The medical records of women taking part in the first 2 prospective adjuvant CMF
(cyclophosphamide, methotrexate, fluorouracil) programs were reviewed to evaluate the incidence
of liver damage which could be attributable to prolonged methotrexate administration. In ... Cited by 14 - Related articles
RB Drotman, GT Lawhorn - Drug and Chemical Toxicology, 1978 - informahealthcare.com Page 1. DRUG AND CHEMICAL TOXICOLOGY, 1(2), 163-171 (1978) SKRUM
ENZYMES AS INDICATORS OF CHKMICAUY INDUCED LIVER DAMAGE RB
Drotman and G. T. Lawhorn The Procter & Gamble Company Miami ... Cited by 55 - Related articles - All 4 versions
[CITATION] L'antihistaminique 3277RP (Phenergan) agit-il curativement dans la tuberculose …
