CM AMBRUS, S ANTHONE, C HORVATH, … - Annals of internal …, 1987 - Am Coll Physicians Multitubular enzyme reactors with immobilized enzymes were developed to achieve depletion
of circulating substrate by extracorporeal means. To act as prototypes, reactors were prepared
with immobilized L-phenylalanine ammonia-lyase, an enzyme that metabolizes ... Cited by 19 - Related articles - All 5 versions
JA Hoskins, G Jack, HE Wade, RJ Peiris, EC Wright, DJ … - Lancet, 1980 - ncbi.nlm.nih.gov The plant enzyme phenylalanine ammonia lyase (PAL) will survive in the gut for long enough
to deplete the phenylalanine derived from food protein and so reduce the rise in blood phenylalanine
that otherwise occurs after a protein meal. This effect has been demonstrated in healthy ... Cited by 31 - Related articles - All 3 versions
L Bourget, TM Chang - Biochimica et biophysica acta, 1986 - ncbi.nlm.nih.gov Microencapsulation of the enzyme phenylalanine ammonia-lyase was developed for in vivo
depletion of systemic phenylalanine in phenylketonuric rats. Compared to normal rats, systemic
phenylalanine blood levels in phenylketonuric rats was increased by 15-20-fold. Daily ... Cited by 26 - Related articles - All 2 versions
FA Hommes - Journal of Inherited Metabolic Disease, 1989 - Springer Extensive investigations have provided evidence for the existence of two mechan- isms for the
transport of neutral amino acids (histidine, isoleucine, leucine, methion- ine, phenylalanine,
tryptophan, tyrosine and vatine) into the brain via the blood- brain barrier. The kinetic ... Cited by 18 - Related articles - All 2 versions
S Safos - Artificial Cells, Blood Substitutes and Biotechnology, 1995 - informahealthcare.com The presence of an extensive enterorecirculation of amino acids between the intestine and the
body' allows the removal of systeniic phenylalanine in PKU rats by oral microencapsulated phenylalanine
ammonia lyase'. The work presented in this article has the main goal of assessing the ... Cited by 18 - Related articles - BL Direct - All 4 versions
J Pietz, R Landwehr, A Kutscha, H Schmidt, L de … - The Journal of pediatrics, 1995 - Elsevier Nevertheless, in otherwise healthy patients with PKU, the motivation to adhere to a strict diet
usually decreases during adolescence despite medical recommendations. For patients who
are no longer able or willing to adhere to the diet, there has been a continuing search for “ ... Cited by 27 - Related articles - BL Direct - All 9 versions
H Dotremont, B Francois, M Diels, P Gillis - Journal of inherited metabolic …, 1995 - Springer Phenylketonuria (PKU; McKusick 261600) is an inherited metabolic disorder caused by a deficiency
of phenylalanine hydroxylase. Hyperphenylataninaemia results in progressive mental
deterioration, unless treatment with dietary phenylalanine (phe) restriction starts before 6 ... Cited by 11 - Related articles - BL Direct - All 7 versions
- ►pnas.org CN Sarkissian, Z Shao, F Blain, R … - Proceedings of the …, 1999 - National Acad Sciences Phenylketonuria (PKU), with its associated hyperphenylalaninemia (HPA) and mental
retardation, is a classic genetic disease and the first to have an identified chemical cause of impaired
cognitive development. Treatment from birth with a low phenylalanine diet largely ... Cited by 89 - Related articles - BL Direct - All 11 versions
[CITATION] First evidence that extra-cerebral recombinant phenylalanine ammonia lyase …
C Sarkissian, D Boulais, Z Shao, M Pedneault, R Heft, … - Am. J. Hum. Genet, 2003 Cited by 2 - Related articles
