RC Hubbard, ML Brantly, SE Sellers, ME … - Annals of Internal Medicine, 1989 - Am Coll Physicians Study Objective: To determine if aerosolization of purified human plasma
α1-antitrypsin is an effective means for increasing lower respiratory
anti-neutrophil-elastase defenses in α1-antitrypsin deficiency. Cited by 65 - Related articles - All 3 versions
- ►nih.gov [PDF] RC Hubbard, NG McElvaney, SE Sellers, JT … - Journal of Clinical Investigation, 1989 - pubmedcentral.nih.gov Alpha 1-antitrypsin(alAT)I deficiency is a genetic disorder characterized by low
plasma and lung levels ofa lAT and the development of emphysema by the third to
fourth decades (1, 2). The deficiency of alAT in the lower respiratory ... Cited by 50 - Related articles - All 4 versions
RC Hubbard, RG Crystal - Lung, 1990 - Springer Abstract. a-antitrypsin (AAT) deficiency is a genetic disease in which low serum
and lung levels of the antiprotease AAT cause a deficiency of the anti- elastase
defensive screen of the lower respiratory tract such that neutrophil ... Cited by 48 - Related articles - All 3 versions
- ►nih.gov [PDF] JE Gadek, HG Klein, PV Holland, RG Crystal - Journal of Clinical Investigation, 1981 - pubmedcentral.nih.gov ABSTRA C T The emphysema associated with the in- herited serum deficiency
ofal-antitrypsin appears to re- sult from an imbalance between neutrophil
elastase and its major inhibitor within the alveolar structures. In the ... Cited by 114 - Related articles - All 4 versions
RC Hubbard, S Sellers, D Czerski, L Stephens … - Jama, 1988 - Am Med Assoc The hereditary disorder alpha 1-antitrypsin (alpha 1AT) deficiency results in
the development of emphysema due to a diminished anti-neutrophil elastase screen
of the lower respiratory tract. Specific therapy for this disorder is ... Cited by 98 - Related articles - All 2 versions
- ►nih.gov [PDF] RM Smith, LD Traber, DL Traber, RG Spragg - Journal of Clinical Investigation, 1989 - pubmedcentral.nih.gov Augmentation of lung antiprotease levels may bean important therapeutic
interventionin the prevention of pulmonary em- physema. We have administered
aerosols of plasma-derived human alpha, proteinase inhibitor (AlPI) to the ... Cited by 27 - Related articles - All 7 versions
MA Casolaro, G Fells, M Wewers, JE Pierce, F … - Journal of Applied Physiology, 1987 - Am Physiological Soc MA CASOLARO, G. FELLS, M. WEWERS, JE PIERCE, F. OGUSHI, R. HUBBARD, ... S.
SELLERS, J. FORSTROM, D. LYONS, G. KAWASAKI, AND RG CRYSTAL ... Pulmonary
Branch, and Section on Laboratory Animal Medicine and Surgery, National ... Cited by 39 - Related articles - All 5 versions
MD Wewers, JE Gadek, BA Keogh, GA Fells, … - The American review of respiratory disease, 1986 - ncbi.nlm.nih.gov 1: Am Rev Respir Dis. 1986 Sep;134(3):476-80. Evaluation of danazol therapy
for patients with PiZZ alpha-1-antitrypsin deficiency. ... Cited by 33 - Related articles - All 3 versions
MD Wewers, MA Casolaro, SE Sellers, SC … - New England Journal of Medicine, 1987 - content.nejm.org In patients with alpha 1-antitrypsin deficiency, the development of emphysema is
believed to be caused by the unchecked action of proteases on lung tissue. We
evaluated the feasibility, safety, and biochemical efficacy of intermittent ... Cited by 328 - Related articles - All 4 versions
- ►171.66.122.149 RA Stockley, DL Bayley, I Unsal, LJ Dowson - American journal of respiratory and critical care …, 2002 - 171.66.122.149 1-Antitrypsin (AAT) deficiency predisposes to bronchitis and emphysema
associated with neutrophilic airway inflammation. The efficacy of augmentation
therapy has not been proven clinically or by demonstrating an effect on ... Cited by 77 - Related articles - BL Direct - All 5 versions
