JE Parrillo, MM Parker, C Natanson, AF … - Annals of Internal Medicine, 1990 - Am Coll Physicians Septic shock is the commonest cause of death in intensive care units. Although
sepsis usually produces a low systemic vascular resistance and elevated cardiac
output, strong evidence (decreased ejection fraction and reduced response ... Cited by 828 - Related articles - All 4 versions
… SL BACHARACH, MV GREEN, C NATANSON … - Annals of internal medicine, 1984 - Am Coll Physicians To characterize the role of cardiac function in septic shock, serial
radionuclide cineangiographic and hemodynamic evaluations were done on 20
patients with documented septic shock. Although all patients had a normal ... Cited by 727 - Related articles - All 4 versions
AF Suffredini, RE Fromm, MM Parker, M … - New England Journal of Medicine, 1989 - content.nejm.org Marked abnormalities in cardiovascular function accompany septic shock, and
bacterial endotoxin is believed to be one of the principal mediators of these
abnormalities. To evaluate the cardiovascular effects of endotoxemia in ... Cited by 770 - Related articles - All 4 versions
JE Parrillo - The New England journal of medicine, 1993 - nejm.highwire.org One of the most frequent and serious problems confronting clinicians is the
management of a serious infection and the systemic response to infection, a
syndrome termed sepsis. When this syndrome results in hypotension and organ ... Cited by 1374 - Related articles - BL Direct - All 6 versions
RC Bone - Annals of internal medicine, 1991 - Am Coll Physicians Sepsis and its sequelae (sepsis syndrome and septic shock) are increasingly
common and are still potentially lethal diagnoses. Many mediators of the
pathogenesis of sepsis have recently been described. These include tumor ... Cited by 1158 - Related articles - All 3 versions
EJ Ziegler, CJ Fisher, CL Sprung, RC Straube … - New England Journal of Medicine, 1991 - content.nejm.org BACKGROUND. HA-1A is a human monoclonal IgM antibody that binds specifically to
the lipid A domain of endotoxin and prevents death in laboratory animals with
gram-negative bacteremia and endotoxemia. METHODS. To evaluate the efficacy ... Cited by 965 - Related articles - All 5 versions
- ►nih.gov [PDF] JE Parrillo, C Burch, JH Shelhamer, MM … - Journal of Clinical Investigation, 1985 - pubmedcentral.nih.gov We have previously described a subpopulation of patients with septic shock who
had a reversible depression ofradionuclide- determined left ventricular ejection
fraction (EF).To investigate the mechanism of this myocardial depression, ... Cited by 460 - Related articles - All 5 versions
- ►rupress.org [PDF] C Natanson, PW Eichenholz, RL Danner, PQ … - Journal of Experimental Medicine, 1989 - jem.rupress.org Endotoxin, an LPS found in theouter membrane of Gram-negative bacteria, has been
considered by many to be the principal toxin involved in the pathogenesis of
Gram-negative septic shock (1). However, it is nowclearthat endotoxin may ... Cited by 394 - Related articles - All 3 versions
MM PARKER, JH SHELHAMER, C NATANSON … - Critical care medicine, 1987 - journals.lww.com Forty-eight septic shock patients with positive blood cultures had conventional
serial hemodynamic evaluations until recovery or death to identify early
cardiovascular variables that predicted outcome. There were 19 (40%) ... Cited by 259 - Related articles - All 3 versions
