- ►annals.org GP Chrousos, SD Detera-Wadleigh, M … - Annals of Internal …, 1993 - Am Coll Physicians Glucocorticoid resistance results from the partial, albeit apparently generalized, inability of glucocorticoids
to exert their effects on target tissues. The condition is associated with compensatory increases
in circulating pituitary corticotropin and cortisol, with the former causing excess secretion ... Cited by 139 - Related articles - BL Direct - All 3 versions
M Karl, SW Lamberts, SD Detera-Wadleigh, IJ … - Journal of Clinical …, 1993 - Endocrine Soc Page 1. 0021-972X/93/7603-0$03.00/0 Journal of Clinical Endocrinology and Metabolism
Copyright Q 1993 by The Endocrine Society Vol. '76, No. :i Printed in UL'3.A. Familial
Glucocorticoid Resistance Caused by a Splice Site Deletion in the Human Glucocorticoid Receptor ... Cited by 139 - Related articles - BL Direct - All 4 versions
M Karl, SW Lamberts, JW Koper, DA Katz, NE … - Proceedings of the …, 1996 - ncbi.nlm.nih.gov Generalized glucocorticoid resistance is associated with chronic hyperactivation of the
hypothalamic-pituitary-adrenal axis, compensating for impaired glucocorticoid receptor
function. We report a unique patient with sporadic generalized glucocorticoid resistance ... Cited by 89 - Related articles - BL Direct
- ►nih.gov [PDF] DM Hurley, D Accili, CA Stratakis, M Karl, … - Journal of Clinical …, 1991 - pubmedcentral.nih.gov Familial glucocorticoid resistance is a hypertensive, hyperan- drogenic disorder characterized
by increased serum cortisol concentrations in the absence of stigmata of Cushing's syn-
drome. Our previous studies of the first reported kindred showed a two- to threefold ... Cited by 216 - Related articles - All 7 versions
- ►nih.gov [PDF] GP Chrousos, A Vingerhoeds, D Brandon, … - Journal of Clinical …, 1982 - pubmedcentral.nih.gov ABSTRA C T We have studied a man suspected of having primary cortisol resistance on the
basis of high 24-h mean plasma cortisol levels (27.4 ug/dl) and no stigmata of Cushing's
syndrome. His son had slightly elevated 24-h mean plasma cortisol levels (9.9 sg/dl; ... Cited by 105 - Related articles - All 5 versions
ACM Vingerhoeds, JHH Thijssen, F … - Journal of Clinical …, 1976 - Endocrine Soc A very high cortisol production rate (CPR) with elevated plasma ACTH was found in a
hypertensive, hypokalemic, but otherwise healthy male patient. There were no symptoms or signs
of Cushing's syndrome. The hypercortisolism appeared to be of the pituitary dependent ... Cited by 83 - Related articles - All 2 versions
- ►nih.gov [PDF] DM Malchoff, A Brufsky, G Reardon, P … - Journal of Clinical …, 1993 - pubmedcentral.nih.gov The precise molecular abnormalities that cause primary corti- sol resistance have not been completely
described. In a subject with primary cortisol resistance we have observed glucocorti- coid receptors
(hGR) with a decreased affinity for dexametha- sone. We hypothesize that a mutation of ... Cited by 125 - Related articles - BL Direct - All 6 versions
SW Lamberts, JW Koper, P Biemond, FH Den … - Journal of Clinical …, 1992 - Endocrine Soc ABSTRACT. Primary (partial) cortisol receptor resistance was previously reported in a total of
7 patients and 14 asymp- tomatic family members. Its occurrence is considered to be extremely
rare. In the present study we report on 6 patients (2 males and 4 females) with the ... Cited by 84 - Related articles - All 3 versions
- ►endojournals.org BB Mendonca, MV Leite, M de Castro, T Kino, … - Journal of Clinical …, 2002 - Endocrine Soc Familial glucocorticoid resistance is characterized by increased cortisol secretion without clinical
evidence of hypercortisolism, but with manifestations of androgen and mineralocorticoid
excess. This condition is mainly caused by mutations of the GR gene that cause ... Cited by 41 - Related articles - BL Direct - All 4 versions
CA Stratakis, M Karl, HM Schulte, GP … - Annals of the New York …, 1994 - ncbi.nlm.nih.gov Familial glucocorticoid resistance (FGR) is a rare hereditary disorder characterized by hypercortisolism
and the absence of stigmata of Cushing's syndrome. The inability of glucocorticoids to exert their
effects on target tissues is compensated for by increases in circulating corticotropin ... Cited by 22 - Related articles - BL Direct - All 5 versions
