- ►annals.org NN Ramzan, E Loftus Jr, LJ Burgart, M … - Annals of internal medicine, 1997 - Am Coll Physicians Background: Whipple disease is a chronic, multisystem disorder associated with
infection with Tropheryma whippelii, an organism that has not yet been grown on
artificial media. In some cases, the diagnosis of Whipple disease is ... Cited by 159 - Related articles - BL Direct - All 4 versions
HU Ehrbar, P Bauerfeind, F Dutly, HR Koelz, … - The Lancet, 1999 - Elsevier We investigated 105 patients (60 men, aged 20-80 years) referred for elective
gastroscopy without clinical signs of Whipple's disease. The study was approved
by the ethics committee of the University of Zurich, and informed consent ... Cited by 99 - Related articles - BL Direct - All 7 versions
S Street, HD Donoghue, GH Neild - The Lancet, 1999 - Elsevier Tropheryma whippelii is the putative pathogen in Whipple's disease. It has not
been cultured, but has been propagated in deactivated macrophages. On the basis
of its 16S ribosomal RNA (rRNA) gene sequence, it is related to the group B ... Cited by 94 - Related articles - BL Direct - All 5 versions
A Von Herbay, HJ Ditton, F Schuhmacher, M … - Gastroenterology, 1997 - Elsevier METHODS: A total of 39 CSF samples and 2 brain biopsy specimens that were
obtained from 24 patients with Whipple's disease at various intervals after
diagnosis were examined. Five patients presented with neurological ... Cited by 99 - Related articles - BL Direct - All 5 versions
G Schoedon, D Goldenberger, R Forrer, A Gunz … - The Journal of infectious diseases, 1997 - UChicago Press Whipple's disease is a systemic illness caused by a specific agent. Despite
recognition of bacteria in lesions, efforts to isolate the causative agent
remained futile. A novel strategy was devised to culture Whipple bacilli in ... Cited by 129 - Related articles - BL Direct - All 5 versions
JL Fleming, RH Wiesner, RG Shorter - Mayo Clinic proceedings. Mayo Clinic, 1988 - ncbi.nlm.nih.gov Whipple's disease is a chronic systemic illness, the optimal treatment of which
remains poorly defined. In our analysis of a 30-year, 29-patient experience with
Whipple's disease at the Mayo Clinic, the frequent initial manifestations ... Cited by 165 - Related articles - All 2 versions
- ►nih.gov M Maiwald, F Schuhmacher, HJ Ditton, A von … - Applied and Environmental Microbiology, 1998 - Am Soc Microbiol Whipple's disease is a systemic disorder in which a gram-positive rod-shaped
bacterium is constantly present in infected tissues. After numerous unsuccessful
attempts to culture this bacterium, it was eventually characterized by 16S ... Cited by 102 - Related articles - BL Direct - All 10 versions
D Raoult, ML Birg, BL Scola, PE Fournier, M … - The New England journal of medicine, 2000 - nejm.highwire.org Results The bacterium of Whipple's disease was grown successfully in HEL cells,
and we established subcultures of the isolate. Indirect immunofluorescence
assays showed that the patient's serum reacted specifically against the ... Cited by 227 - Related articles - BL Direct - All 6 versions
GE Feurle, T Marth - Digestive diseases and sciences, 1994 - Springer Whipple's disease is a multisystemic disorder in which almost all organ systems
can be invaded by rod-shaped bacteria. Without extended antimicrobial therapy,
its course is lethal. Empirically, treatment consists of tetracyclines ... Cited by 70 - Related articles - BL Direct - All 3 versions
