- ►annals.org [PDF] M Feldman, AT McMahon - Annals of internal medicine, 2000 - Am Coll Physicians Two forms of cyclooxygenase, cyclooxygenase-1 (COX-1) and cyclooxygenase 2
(COX-2), act as rate-limiting en- zymes in prostaglandin and thromboxane
synthesis. Dis- covery of these compounds led to the development of drugs ... Cited by 147 - Related articles - BL Direct - All 3 versions
PE Lipsky, P Brooks, LJ Crofford, R DuBois, … - Archives of Internal Medicine, 2000 - archinte.highwire.org Since the synthesis of aspirin 100 years ago, nonsteroidal anti-inflammatory
drugs (NSAIDs) have become mainstays in the medical management of pain and
inflammation. 1 The common but perhaps not the only mechanism underlying ... Cited by 135 - Related articles - BL Direct - All 4 versions
L Laine, S Harper, T Simon, R Bath, J … - Gastroenterology, 1999 - Elsevier Selectivity of COX inhibitors may be measured by assays of prostaglandin
production in whole blood. COX-1 activity is measured by thromboxane B 2
generation in clotting whole blood, and COX-2 activity is assessed by ... Cited by 399 - Related articles - BL Direct - All 11 versions
C Hawkey, L Laine, T Simon, A Beaulieu, J … - Arthritis and rheumatism, 2000 - cat.inist.fr Objective. This randomized, double-blind study tested the hypothesis that
rofecoxib, a drug that specifically inhibits cyclooxygenase 2, would cause fewer
gastroduodenal ulcers than ibuprofen(in a multicenter trial), and its side ... Cited by 265 - Related articles - BL Direct - All 2 versions
- ►oxfordjournals.org [PDF] J Dequeker, C Hawkey, A Kahan, K Steinbruck … - Rheumatology, 1998 - Br Soc Rheumatology S is a large-scale, prospective, international, multicentre,
double-blind, double-dummy, randomized, parallel-group trial. Patients with
exacerbation of osteoarthritis were treated with the recommended dose of ... Cited by 197 - Related articles - BL Direct - All 4 versions
A Porto, H Almeida, MJ Cunha, A Macciocchi - European journal of rheumatology and inflammation, 1994 - ncbi.nlm.nih.gov The gastric tolerability of nimesulide, a new nonsteroidal anti-inflammatory
drug (NSAID), was compared with diclofenac, an established NSAID for the
treatment of osteoarthritis (OA). A randomised, double-blind parallel group ... Cited by 27 - Related articles - BL Direct - All 2 versions
P Bourgeois, RL Dreiser, MG Lequesne, A … - European journal of rheumatology and inflammation( …, 1994 - cat.inist.fr Multi-centre double-blind study to define the most favourable dose of nimesulide
in terms of efficacy/safety ratio in the treatment of osteoarthritis. ... Cited by 35 - Related articles - BL Direct - All 2 versions
LS Simon, AL Weaver, DY Graham, AJ Kivitz, … - Jama, 1999 - Am Med Assoc You are seeing this message because your Web browser does not support basic Web
standards. Find out more about why this message is appearing and what you can do
to make your experience on this site better. ... Context In vitro studies ... Cited by 729 - Related articles - BL Direct - All 4 versions
- ►aspetjournals.org KC Zimmermann, M Sarbia, K Schror, AA … - Molecular pharmacology, 1998 - ASPET Selective cyclooxygenase (COX)-2 inhibitors are expected to cause fewer gastric
side effects because of sparing of COX-1-dependent prostaglandin (PG) synthesis
in the gastric mucosa. However, the possible contribution of COX-2 to ... Cited by 86 - Related articles - BL Direct - All 4 versions
